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相关实验视频

Updated: May 9, 2025

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

识别年龄调节化合物使用一个新的计算框架来评估转录年龄.

Chao Zhang^1,2,3, Nathalie Saurat^4,5, Daniela Cornacchia^4,5

¹Section of Computational Biomedicine, Boston University School of Medicine, Boston, Massachusetts, USA.

|May 1, 2025

概括

研究人员开发了RNAge,这是一种评估细胞衰老的计算工具. 该平台确定了可以诱导衰老或复苏的新型化合物,有助于疾病建模和治疗与年龄有关的疾病的开发.

关键词:

阿尔茨海默氏症的疾病是阿尔茨海默氏症.年龄分数年龄分数老化的老化衰老的老化皮层神经元,皮层神经元.疾病建模疾病建模人类多能干细胞干细胞转录年龄转录年龄

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Last Updated: May 9, 2025

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

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Published on: March 7, 2018

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科学领域:

干细胞生物学干细胞生物学
计算生物学是一种计算生物学.
衰老的研究研究.

背景情况:

人类多能干细胞 (hPSCs) 提供多种细胞类型,但通常代表胎儿阶段.
模拟晚期发病的疾病需要方法来诱导hPSC衍生细胞的细胞衰老.
现有的方法来加速hPSC系的衰老是有限的.

研究的目的:

介绍RNAge,一个基于转录基因的计算平台,用于评估诱导衰老和青春.
在不同的数据集中验证RNAge并评估其用于评估年龄调节干预措施的实用性.
在细胞模型中确定用于诱导衰老或再生的新化合物.

主要方法:

开发了RNAge,这是一个计算平台,分析转录组以量化细胞年龄状态.
使用来自各种组织和物种的独立数据集验证RNAge.
在使用LINCS L1000数据集和实验验证的基化合物选中进行.

主要成果:

RNAge有效地评估诱导衰老和再生状态,并评估干预措施.
确定并证实了诱导纤维细胞和hPSC衍生神经元衰老或再生的新型化合物.
将诱导衰老应用于阿尔茨海默病 (AD) hPSC模型加速了基因型特异的神经退行.

结论:

RNAge提供了一种强大的方法来量化与年龄相关的细胞操纵.
发现的化合物显著扩大了hPSC衍生细胞中年龄修饰策略的工具包.
这种方法增强了使用干细胞衍生模型对包括阿尔茨海默病在内的与年龄有关的疾病的建模.