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皮质类固醇使用和体重和腰围的长期变化:生命线队列研究
Mostafa Mohseni1,2, Eline S van der Valk1,2, Maartje J B Van der Hurk1
1Obesity Center CGG, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2400, 3000 CA Rotterdam, the Netherlands.
概括
皮质类固醇的使用,包括局部形式,与长期体重增加和腰围增加有关,特别是在女性和超重者中. 停止使用皮质类固醇可以减少腰围,有助于肥胖管理.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 肥胖问题研究研究
背景情况:
- 皮质类固醇 (CS) 与体质指数 (BMI) 和腰围 (WC) 在横截面研究中增加有关.
- 关于CS对体重和WC的影响的纵向数据,特别是局部形式,是有限的.
研究的目的:
- 调查皮质类固醇使用与体重和WC的变化之间的纵向关联.
- 根据给药途径 (全身与局部) 和患者特征,检查这些影响的差异.
主要方法:
- 分析了生命线队列研究中的81,361名参与者的体重和WC变化,平均随访时间为3.9年.
- 使用了线性回归模型,敏感性分析按性别和BMI分层.
- 开始后的短期体重变化被评估为一个子集,使用线性混合效应模型.
主要成果:
- 新的皮质类固醇使用者比非使用者增加了显著的体重 (0.034公斤/年),特别是当地的CS启动 (0.037公斤/年).
- 系统性CS使用增加了WC (0.200厘米/年),而停药减少了WC (-0.078厘米/年).
- 这些影响在女性和BMI≥25 kg/m2的个体中更为明显,但在男性或BMI<25 kg/m2的个体中并非如此.
结论:
- 皮质类固醇的使用,包括局部形式,与长期增加体重和WC有关,特别是在女性和超重/肥胖个体中.
- 停用皮质类固醇与减少的WC相关,这表明对与肥胖相关的结果有潜在的益处.
- 需要仔细考虑慢性CS使用,并有可能停止使用以改善代谢健康.
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