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相关概念视频

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Integration of Synaptic Events01:28

Integration of Synaptic Events

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Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability...
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Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

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When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
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Synaptic Signaling01:09

Synaptic Signaling

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Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
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Chemical Synapses01:26

Chemical Synapses

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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
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The Synapse02:47

The Synapse

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Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
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相关实验视频

Updated: May 9, 2025

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
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在ZDHHC9-关联神经发育障碍中的突触功能和感官处理:一个机械的帐户

Rebeca Ianov Vitanov1, Jascha Achterberg1, Danyal Akarca1

  • 1MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.

The European journal of neuroscience
|May 1, 2025
PubMed
概括

功能丧失的 ZDHHC9 变体会损害大脑功能,可能是通过减少神经抑制. 这项研究使用MEG和计算建模来揭示ZDHHC9如何影响皮质活动和认知.

关键词:
在MEGEG中,MEG是MEG.在 ZDHHC9 的情况下.是一种.智力障碍 智力障碍是一种智力障碍.语言语言语言语言语言语言.经常性的神经网络.

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Paired Whole Cell Recordings in Organotypic Hippocampal Slices

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科学领域:

  • 神经科学是一个神经科学.
  • 计算生物学 计算生物学
  • 遗传学 是一个遗传学.

背景情况:

  • ZDHHC9基因中的功能丧失变异与X链接智力障碍 (XLID),罗兰 (RE) 和发育性语言障碍有关.
  • 了解ZDHHC9相关的神经发育状况背后的神经机制对于有针对性的干预至关重要.

研究的目的:

  • 研究ZDHHC9相关的皮质功能和认知差异背后的神经机制.
  • 将人类神经生理学数据与计算建模相结合,以解释ZDHHC9的影响.

主要方法:

  • 磁脑摄影 (MEG) 用于记录ZDHHC9变体和对照个体的听觉唤起场 (AEF) 和磁性不匹配负面性 (mMMN).
  • 开发了一种循环神经网络 (RNN) 模型,以模拟听觉唤起的反应,并测试突触功能障碍的影响.

主要成果:

  • 患有ZDHHC9变异的个体在AEF中表现出更大的振幅和以后的峰值延迟,以及增加的mMMN振幅,表明神经处理发生了变化.
  • RNN模型模拟表明,减少抑制性突触权重重复述了引起反应中观察到的群体差异.
  • 加强激发性连接没有产生类似的结果,支持减少抑制的作用.

结论:

  • 减少神经抑制是解释ZDHHC9功能丧失对感官处理期间皮质动态影响的可能机制.
  • 这些发现为ZDHHC9相关的神经发育条件提供了潜在的神经基础.