Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Membrane Fluidity01:26

Membrane Fluidity

10.7K
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
10.7K
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

7.0K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
7.0K
What are Lipids?01:38

What are Lipids?

192.3K
Overview
192.3K
Membrane Lipids01:32

Membrane Lipids

20.2K
Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
20.2K
The Fluid Mosaic Model01:34

The Fluid Mosaic Model

142.2K
The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.
142.2K
Fluid Mosaic Model01:19

Fluid Mosaic Model

11.1K
Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
11.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Surgical Insights and Therapeutic Challenges in the Management of Giant Complex Vascular Malformation of the Buttock.

Journal of Indian Association of Pediatric Surgeons·2026
Same author

Modulation of the Unfolded Protein Response by Viruses: Mechanistic Insights and Implications for viral Pathogenesis.

Current protein & peptide science·2026
Same author

Virus-like particles: Bridging immunization and precision drug delivery.

Gene·2026
Same author

Design and Evaluation of Semi-Synthetic Morin Derivatives as Promising Antitumor Agents against Breast and Liver Cancer.

Current drug discovery technologies·2026
Same author

Herbal remedies for hepatic diseases: A review of medicinal herbs in the treatment of liver disorders.

Chinese herbal medicines·2026
Same author

Lipocentric Non-Pore-Forming Membrane Depolarization Underlies the Antibacterial Activity of Ribosomal Protein S30.

The journal of physical chemistry letters·2026
Same journal

Controlled Secondary Growth of CAU-1-NH<sub>2</sub> Membranes with Improved CO<sub>2</sub> Separation Performance.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Facile Fabrication and Stable Mechanism of a Microscale Heavy Calcium Carbonate Suspension.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Polycationic Biocidal Coatings: The Mechanism of Their Interaction with Cells.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Atomic-Scale Displacement in Ordered SmMnO<sub>3</sub> Nanoislands.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Vacancy Defect Modulated Interfacial Thermal Transport and Phonon Localization in AlGaN/GaN Heterojunctions.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Immobilization of Ytterbium via Polyphenol Chemistry on Implant Materials for Enhanced Cytocompatibility and Antibacterial Properties.

Langmuir : the ACS journal of surfaces and colloids·2026
查看所有相关文章

相关实验视频

Updated: May 14, 2025

Fluorescence Recovery after Merging a Droplet to Measure the Two-dimensional Diffusion of a Phospholipid Monolayer
07:54

Fluorescence Recovery after Merging a Droplet to Measure the Two-dimensional Diffusion of a Phospholipid Monolayer

Published on: October 15, 2015

8.0K

量化离子液体亲和力及其对脂膜结构和动态的影响.

Veerendra K Sharma1,2, Jyoti Gupta1,2, Harish Srinivasan1,2

  • 1Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai 400085, India.

Langmuir : the ACS journal of surfaces and colloids
|May 1, 2025
PubMed
概括
此摘要是机器生成的。

离子液体 (ILs) 破坏脂质膜,增加流动性和毒性. 在IL上较长的基链会导致更显著的膜乱和增强的脂质扩散.

更多相关视频

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
10:58

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions

Published on: July 27, 2017

9.4K
Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions
10:02

Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions

Published on: May 27, 2021

3.9K

相关实验视频

Last Updated: May 14, 2025

Fluorescence Recovery after Merging a Droplet to Measure the Two-dimensional Diffusion of a Phospholipid Monolayer
07:54

Fluorescence Recovery after Merging a Droplet to Measure the Two-dimensional Diffusion of a Phospholipid Monolayer

Published on: October 15, 2015

8.0K
PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
10:58

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions

Published on: July 27, 2017

9.4K
Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions
10:02

Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions

Published on: May 27, 2021

3.9K

科学领域:

  • 生物膜科学是生物膜科学.
  • 物理化学 物理化学
  • 毒理学 毒理学 毒理学

背景情况:

  • 了解离子液 (IL) 与生物膜的相互作用对于制药应用和解释IL诱导的生物效应至关重要.
  • 基于伊米达的IL被广泛研究,因为它们在各种应用中的潜力,需要清楚地了解它们的膜相互作用.

研究的目的:

  • 为了研究不同基链长度的基于伊米达的IL如何影响二聚酸酸胆 (DPPC) 模型膜的粘性弹性,动力学和相位行为.
  • 阐明IL基链长度在调节膜性质和脂质扩散中的作用.

主要方法:

  • 使用的模型膜系统:由DPPC组成的脂质单层和单层状囊泡.
  • 采用富里埃变换红外光谱学 (FTIR) 和准弹性中子散射 (QENS) 来分析膜结构和动力学.
  • 进行分子动力学 (MD) 模拟,以补充实验发现,并提供分子层面的见解.

主要成果:

  • 无论是1-decyl-3-methylimidazolium化物 (DMIM[Br]) 还是1-hexyl-3-methylimidazolium化物 (HMIM[Br]) 都诱导了膜乱,改变了每脂质和粘弹性特性的面积.
  • 较长的基链在ILs上导致更强的膜相互作用,增加了障碍,较低的相位过渡温度,以及更多的左边缺陷.
  • ILs显著增强了脂质横向扩散,在有序的膜相中,在较高的IL度和较长的IL链下,效果更为明显.

结论:

  • 离子液体,特别是具有较长基链的液体,会破坏脂质膜组织,增加流动性和透性.
  • 增强的膜流动性和透性与增加的IL毒性相关,提供了一种机械联系.
  • 这些发现为IL-生物膜相互作用提供了关键的见解,为其毒理学概况和药物开发提供了信息.