Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.7K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.7K
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

43.0K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
43.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Fluxomics in precision nutrition: integrating dynamic metabolic profiling with multiomics.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
Same author

Identification of High-Performing Blood Metabolite Biomarkers of Lung Cancer in a Chinese Population.

Phenomics (Cham, Switzerland)·2026
Same author

Automated, targeted, NMR spectral profiling of human breast milk.

Metabolomics : Official journal of the Metabolomic Society·2026
Same author

Serum metabolomic profiling reveals LysoPC/PC depletion as a potential biomarker to detect avian reoviral infection in neonatal broiler chickens.

Frontiers in cellular and infection microbiology·2026
Same author

The NMR Exchange Format (NEF): Specification and Applications.

bioRxiv : the preprint server for biology·2026
Same author

A scoring system for validity assessment of biomarkers of food intake.

Critical reviews in food science and nutrition·2026

相关实验视频

Updated: May 9, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.0K

BASys2:一个下一代细菌基因组注释系统.

Jenna Poelzer1, Scott Han1, Sukanta Saha1

  • 1Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.

Nucleic acids research
|May 1, 2025
PubMed
概括

细菌注释系统2.0 (BASys2) 显著加速细菌基因组注释,提供更快,更全面的分析. 这种先进的系统提供了增强的可视化和更深入的细菌基因组和代谢组的见解.

更多相关视频

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
12:08

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies

Published on: August 20, 2021

4.9K
From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

17.1K

相关实验视频

Last Updated: May 9, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.0K
Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
12:08

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies

Published on: August 20, 2021

4.9K
From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

17.1K

科学领域:

  • 微生物基因组学 微生物基因组学
  • 生物信息学是一种生物信息学.
  • 计算生物学是一种计算生物学.

背景情况:

  • 最初的细菌注释系统 (BASys) 自2005年以来一直是细菌基因组注释的开创性网络服务器.
  • 网络技术和注释算法的进步需要对微生物基因组学工具进行更新.
  • 现有的工具可能无法满足细菌基因组学中对速度,完整性和可视化的不断变化的需求.

研究的目的:

  • 开发一个升级的细菌基因组注释系统 (BASys2),它结合了最近的技术和算法进步.
  • 与之前的BASys版本相比,大大提高了速度,数据输出和可视化功能.
  • 为研究人员提供了一种通用而强大的工具,用于深入分析细菌基因组和代谢组.

主要方法:

  • 开发了BASys2,一个新的系统,采用快速基因组匹配和注释转移策略.
  • 集成了超过30个生物信息学工具和10个数据库,用于全面的注释.
  • 实现了一个交互式基因组查看器,用于动态可视化细菌基因组图和注释.
  • 提供多个接入点:Web服务器,桌面应用程序和Docker图像.

主要成果:

  • BASys2实现了比以前的系统快8000倍的注释速度,将注释时间缩短到10秒.
  • 该系统每基因/蛋白质生成多达62个注释字段,与早期版本相比,数据字段翻了一番.
  • BASys2支持广泛的整个代谢组注释和完整的结构性蛋白质组生成.
  • 交互式观看器可方便动态操作和对基因组数据的详细检查.

结论:

  • BASys2代表了细菌基因组注释的重大进步,提供了前所未有的速度和深度.
  • 该系统的增强可视化和全面的注释功能使微生物基因组学研究得以加强.
  • 作为一个Web服务器,桌面查看器和Docker图像,BASys2可以轻松访问,从而促进广泛的采用和使用.