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Updated: May 9, 2025

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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非糖酸C-O键形成由双功能伪糖转移酶ValL催化

Ziyue Guo1, Xin Zhang1, Lin Zhou1

  • 1State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.

Synthetic and systems biotechnology
|May 1, 2025
PubMed
概括

研究人员在Streptomyces中发现了新的氧桥式有效氨酸类似物. 酶ValL独特地催化了C-O键的形成,扩大了创造新的C7N家族抗生素的可能性.

关键词:
C7N 抗生素是一种抗生素.非糖化的CO键伪糖转移酶是一种假糖转移酶.瓦利达米辛A是一种有效药物.

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