黄素补充剂对认知功能的影响:更新的系统综述和元分析
Wenlong Wang1, Rui Zhao2, Bingzheng Liu2
1Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Frontiers in nutrition
|May 1, 2025
概括
黄素补充剂显著提高了全球认知功能. 最佳效果在0.8克/天至少24周内,特别是在老年亚洲人身上.
科学领域:
- 营养神经科学 营养神经科学
- 药理学 药理学是指药理学的学科.
- 老年学是一门学科.
背景情况:
- 以前的随机对照试验 (RCT) 对黄素对认知功能的影响产生了不一致的发现.
- 现有的研究需要进行全面分析,以澄清黄素对认知功效的益处.
研究的目的:
- 进行RCT的元分析,以确定黄素对认知功能的整体影响.
- 为了确定黄素对认知益处的最佳剂量,持续时间和参与者特征.
主要方法:
- 在包括Web of Science,PubMed,Cochrane Library和Embase在内的主要数据库中进行了系统的搜索.
- 九个RCT包括12个独立的比较和501名参与者被纳入了元分析.
主要成果:
- 与安慰剂相比,黄素补充剂显著改善了全球认知功能 (SMD,0.82;p = 0.010).
- 观察到一种曲线性剂量反应关系,最佳剂量为0.8g/天.
- 对于持续时间≥24周,年龄≥60岁的参与者和来自亚洲国家的参与者来说,好处是显著的.
结论:
- 黄素补充剂有效改善全球认知功能.
- 最佳的治疗方案是每天0.8克,持续≥24周.
- 黄素的认知益处在老年人和亚洲人群中更为明显.
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