在认知正常的老年人中神经精神病症状和死亡率 墨西哥裔美国人
Phillip A Cantu1, Soham Al Snih1, Kyriakos Markides1
1University of Texas Medical Branch, Galveston, USA.
Hispanic journal of behavioral sciences
|May 1, 2025
概括
在没有痴呆症的老年人中,神经精神症状 (NPS) 预测死亡率. 漠不关心,易怒和异常运动行为是关键指标,这表明有可能进行干预以改善生存率.
科学领域:
- 老年学是一门学科.
- 流行病学 流行病学
- 神经科学是一个神经科学.
背景情况:
- 神经精神症状 (NPS) 与痴呆患者的死亡率有关.
- 有限的研究存在于NPS预测非痴呆症人口的死亡率.
- 老年人,特别是墨西哥裔美国人,是衰老研究的关键人口.
研究的目的:
- 研究神经精神症状 (NPS) 作为六年死亡率的预测因素.
- 检查80岁以上社区居住的墨西哥裔美国人中NPS和死亡率之间的关联.
- 确定与认知正常的老年人死亡风险增加相关的特定NPS.
主要方法:
- 利用了466名认知正常参与者的数据 (西班牙裔老年人流行病学研究的确立人口,第7波).
- 使用神经精神科目录 (NPI) 测量NPS.
- 采用Cox的比例危险模型来计算死亡率的危险比率 (HR),控制共变量.
主要成果:
- 总的NPI得分预测死亡率 (HR=1.02).
- 预测死亡率的NPI条件数量 (HR=1.09).
- 漠不关心,易怒和异常运动行为是独立的死亡率预测因素.
结论:
- 在认知上正常的老年人中,NPS是死亡的重要预测因素.
- 诸如冷漠之类的特定症状可能表明潜在的健康问题或是可修改的危险因素.
- 研究结果表明,NPS可能是提高老龄人口寿命的干预措施的目标.
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