爱斯坦-巴尔病毒感染是中度至重度性结肠炎患者手术的独立风险因素
1Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China.
World journal of gastroenterology
|May 1, 2025
概括
肠道内埃普斯坦-巴尔病毒 (EBV) 感染预示着性结肠炎 (UC) 患者需要进行大肠切除术. 结合EBV的新模型有助于UC管理的外科风险评估.
科学领域:
- 胃肠病学 胃肠病学
- 病毒学 病毒学
- 手术瘤学手术瘤学
背景情况:
- 爱斯坦-巴尔病毒 (EBV) 肠道感染与性结肠炎 (UC) 的手术风险有关,但其预测作用尚不清楚.
- 了解EBV的影响对于管理中度至重度UC和预防切除术至关重要.
研究的目的:
- 确定EBV感染是否预测UC患者的胆管切除术的必要性.
- 开发一个UC手术风险预测模型.
主要方法:
- 对153名中度至重度UC患者 (2012-2023) 的回顾性研究.
- 通过EBV编码的小RNA (EBER) 在位杂交和免疫组织化学 (IHC) 检测EBV.
- 细胞巨乳病毒 (CMV) 通过IHC检测;风险因素的后勤回归和模型开发.
主要成果:
- 在接受手术的患者 (40.4%) 与未接受手术 (4.7%) 组 (P < 0.01) 中,EBER阳性显著更高.
- 多变量分析确定了年龄,EBV,CMV感染和多种免疫抑制剂作为独立的胆管切除预测因素.
- 整合这些因素的诺米图显示出良好的预测能力,校准和临床效用.
结论:
- 肠道EBV感染是中度至重度UC科切除术的重要独立风险因素.
- 开发的名图,包括EBV感染,有效地预测UC患者的胆管切除风险.
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