晚期肝内胆管癌转化治疗:机遇和挑战
Jun-Jie Liu1, Mi Zhou1, Tong Yuan1
1Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.
World journal of gastroenterology
|May 1, 2025
概括
肝脏内胆管癌 (ICC) 的预后不好,通常在晚期诊断. 转化治疗在某些晚期ICC患者中提供了手术切除的机会.
科学领域:
- 肝胆道恶性瘤 肝胆道恶性瘤
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 肝脏内胆管癌 (ICC) 的患病率在全球范围内正在上升.
- 呈现出高恶性和潜伏发作的ICC,通常在晚期诊断.
- 手术后的不良预后和高复发率需要新的治疗策略.
研究的目的:
- 审查转化治疗的定义和临床证据,以治疗晚期肝内胆管癌.
- 探索下降转换疗法的作用,以促进晚期ICC的手术切除.
主要方法:
- 文献综述总结了临床经验和关于高级ICC转换治疗的证据.
- 在过去十年中,对先进的ICC进行了研究的各种治疗方式的分析.
主要成果:
- 转化治疗可以促进手术切除在选定患者的高级ICC.
- 为了先进的ICC管理,正在探索各种系统和局部区域疗法.
- 降级转换治疗是改善切除能力的关键策略.
结论:
- 转换治疗是高级ICC的可行选择,旨在使手术切除成为可能.
- 需要进一步的临床证据来优化ICC的转换治疗方案.
- 管理先进的ICC需要多学科的方法,包括转化疗法.
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