皮质类固醇在患有多结核和心周结核的患者的使用
Julie Sang1, Arunee Motes1, Kenneth Nugent1
1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
概括
皮质类固醇可能有助于结核性肺溢液和心膜炎症状,但证据不一致. 需要更多的研究来确定这些肺外结核病并发症的最佳使用.
科学领域:
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
- 心脏病学 心脏病学
背景情况:
- 结核性 (TB) 流和心膜炎是常见的肺外结核并发症.
- 皮质类固醇因其在治疗这些疾病中的抗炎作用而受到研究.
- 目前关于辅助皮质类固醇益处的证据仍然相互矛盾.
研究的目的:
- 审查皮质类固醇作为结核性多叶流血和心周炎的辅助治疗的疗效.
- 确定报告的好处和需要进一步调查的领域的不一致性.
主要方法:
- 审查现有关于皮质类固醇在结核性多叶流血和心周炎中的使用研究.
- 对报告结果的分析,包括症状持续时间,液体再吸收,长期后果和死亡率.
主要成果:
- 皮质类固醇可能会减少结核病的症状持续时间和肺液,但长期的益处是不一致的.
- 对结核病心膜炎的研究显示,有关症状缓解,收缩性心膜炎发病率和死亡率的结果各不相同.
- 总体而言,证据不足以推常规使用皮质类固醇.
结论:
- 虽然皮质类固醇可能会带来一些好处,但它们在肺结核和心周结核的常规使用目前没有足够的证据支持.
- 皮质类固醇治疗的最佳剂量,时间和持续时间仍然是关键的问题.
- 进一步的研究是必不可少的,以确定可能受益于辅助皮质类固醇的患者子组.
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