基于生物材料的方法用于下组织工程:我们在哪里,我们在哪里,我们要去哪里
Maeve M Kennedy1, Antonios G Mikos1
1Department of Bioengineering, Rice University, Houston, TX 77030, USA.
Regenerative biomaterials
|May 1, 2025
概括
这项研究回顾了生物材料的进展,重建关键尺寸下缺陷,超越传统的移植到组织工程植入物. 未来的研究重点是增强植入物,以改善骨再生和患者的治疗结果.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 面外科手术 面外科手术
背景情况:
- 下对于说话,,吞和面部美学至关重要.
- 由于瘤,创伤,感染或先天性疾病的缺陷,需要下重建.
- 自生骨移植在历史上是关键尺寸缺陷的黄金标准.
研究的目的:
- 审查下缺陷重建的基于生物材料的方法的演变.
- 突出目前使用支架,细胞和生物因素的组织工程策略.
- 确定改善下下再生植入物的未来方向.
主要方法:
- 关于下重建生物材料的历史和当前文献的综述.
- 讨论脚手架材料 (合成/天然) 和增材制造技术.
- 在组织工程中使用的细胞类型 (例如,介质干细胞) 和生物因素 (例如,BMP,TGF-β) 的分析.
主要成果:
- 生物材料支架与细胞和生长因子相结合,为移植提供了可调节的,生物灵感的替代品.
- 增材制造可以制造复杂的脚手架结构.
- 取得了显著的进展,但临床翻译方面的挑战仍然存在.
结论:
- 未来的下组织工程需要改进植入物血管化,内化和个性化.
- 加强药物释放的时空控制对于优化再生至关重要.
- 最终的目标是开发能够再生骨的生物材料,这些生物材料在结构和生物学上与本地组织相同.
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