状尿素治疗状细胞疾病:在低收入和中等收入环境中,护理人员的知识和处方模式
Akinyemi O D Ofakunrin1, Edache Sylvanus Okpe2, Rasaq Olaosebikan3
1Department of Paediatrics, Faculty of Clinical Sciences, University of Jos &Jos University Teaching Hospital, Jos, Nigeria.
许多状细胞疾病 (SCD) 提供者缺乏知识和适当的氧尿素处方实践. 需要有针对性的培训,以改善尼日利亚的基尿素使用和患者的治疗结果.
科学领域:
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 氨酸是状细胞疾病 (SCD) 的关键疾病修饰疗法,改善了患者的发病率,死亡率和生活质量.
- 基尿素的不足使用源于提供者知识不足和不一致的处方做法,限制了其治疗潜力.
- 这项研究调查了尼日利亚乔斯的SCD护理提供者之间的酸知识和处方模式.
研究的目的:
- 评估在尼日利亚乔斯管理SCD的医生中关于氧尿素的益处和安全性的知识水平.
- 根据国际指导方针,评估SCD护理中的当前氧尿素处方模式.
- 识别阻碍最佳氧尿素利用的知识和实践上的差距.
主要方法:
- 对132名参与SCD管理的医生进行了横截面调查.
- 收集的数据包括社会人口统计数据,酸知识 (17项规模) 和处方实践.
- 处方模式与NIH (2014) 和BSH (2018) 准则进行了基准测试;使用描述性和推断性统计数据分析数据.
主要成果:
- 超过一半 (50.8%) 的医生对基尿素的临床功效知识不足.
- 对治疗指导方针的认识很低 (26.5%),只有24.2%的人处方了基尿素.
- 在处方者中,观察到与指导方针的显著偏差,包括不适当的启动标准 (28.1%),次治疗剂量 (18.8%),以及不遵守推的最大剂量 (78.1%).
结论:
- 在尼日利亚乔斯的SCD提供者之间,在知识和遵守氧尿素处方指南方面存在很大的差距.
- 不一致的处方做法普遍存在,包括低于最佳剂量和不适当的启动.
- 实施有针对性的教育干预措施至关重要,以增强氧尿素的利用率,并改善患者在SCD管理中的结果.
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