灰质体积与轻度认知障碍的老年患者的认知和运动功能之间的联系
Yue-Bing Yue1, Man-Fei Xu1, Zheng Xu1
1Department of Geratology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, China.
World journal of psychiatry
|May 1, 2025
概括
患有无记忆性轻度认知障碍 (aMCI) 的患者的灰质体积 (GMV) 减少与认知和运动功能的降低有关. 特定的大脑区域,包括额头和头区域,对于步态和日常活动至关重要.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 轻度认知障碍 (MCI) 是正常衰老和阿尔茨海默病 (AD) 之间的过渡阶段.
- 阿姆内斯蒂克MCI (aMCI) 是AD的重要前体,人们对其神经解剖学的基础越来越感兴趣.
- 减少灰质体积 (GMV) 被研究其对aMCI认知和运动衰退的影响.
研究的目的:
- 调查灰色物质体积 (GMV) 与记忆力轻度认知障碍 (aMCI) 患者的认知和运动功能之间的关联.
主要方法:
- 一项涉及45名aMCI患者和45名对照者的横截面研究.
- 基于voxel的形态测量 (VBM) 用于在不同组之间比较GMV.
- 部分相关性和线性回归分析评估了GMV,认知得分和步态参数之间的关系,控制共变量.
主要成果:
- 特定感兴趣区域 (ROI) 的GMV与日常生活活动 (ADL) 评分和认知评估 (MMSE,CAMCOG-C) 相相关.
- 在aMCI患者中,认知功能 (CAMCOG-C) 与步行表现 (TUG持续时间) 有负相关性.
- 减少的左尾GMV与步态受损 (TUG) 相相关,而前和尾区域的GMV与步行速度有关.
结论:
- 在aMCI中,灰质体积的减少与认知和运动障碍有关.
- 前额,后额和中部大脑区域在aMCI中观察到的步态障碍中发挥着关键作用.
- 这些发现凸显了GMV在理解aMCI功能衰退方面的重要性.
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