炎症因素,乳酸水平,急性皮肤衰竭,情绪不佳和睡眠质量之间的关系
Yu-Fei Liu1, Wen Cong2, Chang-Ming Zhou1
1Department of Emergency Critical Care Medicine, The Second Hospital of Dalian Medical University, Dalian 116027, Liaoning Province, China.
World journal of psychiatry
|May 1, 2025
概括
炎症标志物和乳酸水平与急性皮肤衰竭 (ASF) 的严重程度以及败血症患者的情绪和睡眠质量不佳有关. 这突出了改善患者护理的潜在目标.
科学领域:
- 关键护理医学 关键护理医学
- 炎症和免疫学 炎症和免疫学
- 皮肤病学 皮肤病学
背景情况:
- 败血性休克会引发炎症反应,可能导致急性皮肤衰竭 (ASF) 和全身炎症反应综合征.
- 患有败血症休克的重症患者经常经历情绪障碍和睡眠障碍.
- 炎症标志物,乳酸,ASF严重程度,情绪和睡眠质量之间的关系仍未得到充分探索.
研究的目的:
- 调查炎症因素,乳酸水平,ASF严重程度,情绪障碍和败血症患者的睡眠质量之间的相关性.
- 为了确定炎症标志物和乳酸的升高是否与ASF中更糟糕的结果有关.
主要方法:
- 一项对150名败血症休克患者的回顾性研究,分为ASF (n=35) 和非ASF (n=115) 组.
- 两组之间对周围血液炎症标志物 (TNF-α,CRP,IL-6),乳酸,皮肤斑点得分 (SMS),MEWS,SAS,SDS和PSQI得分进行比较.
- 皮尔森相关性分析,以评估测量变量之间的关系.
主要成果:
- 与非ASF组相比,ASF组的CRP,IL-6,prokalcitonin,乳酸,SMS,MEWS,SAS,SDS和PSQI得分明显高于非ASF组 (P < 0.001).与非ASF组相比,ASF组的CRP,IL-6,prokalcitonin,乳酸,SMS,MEWS,SAS,SDS和PSQI得分明显高于非ASF组 (P < 0.001).
- 升高的IL-6,CRP,TNF-α和乳酸水平与SMS,MEWS,SAS,SDS和PSQI得分正相关 (P<0.05).
结论:
- 周围血液中IL-6,CRP,TNF-α和乳酸的水平与严重病患者的ASF严重程度和情绪和睡眠质量低下有关.
- 这些发现表明,炎症标志物和乳酸可能作为ASF和相关心理和睡眠障碍的指标.
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