在肺充血中使用西斯丁,格姆西塔和多克索鲁比辛的临床前经验
Lindsay J Nitsche1, Leslie Curtin2, Sandra Sexton2
1Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY.
JTCVS open
|May 1, 2025
概括
用西斯普拉丁,多克索鲁比辛和格姆奇塔宾进行的肺充血化疗对治疗肺癌显示有前途. 这种方法可以扩大局部药物输送,同时最大限度地降低全身毒性,这表明人体试验的安全性.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 肺部医学 肺部医学
背景情况:
- 肺癌和肺转移是严重的健康问题.
- 目前的化疗通常会导致全身毒性.
- Suffusion提供了一种方法,可以放大肺部化疗的输送,同时限制全身暴露.
研究的目的:
- 评估肺充血用于输送化疗药物的安全性和有效性.
- 通过充血测试候选药物,包括西斯普拉丁,多克索鲁比辛和格姆奇塔宾,用于肺癌治疗.
- 评估系统性毒性和局部药物输送,使用充血方法.
主要方法:
- 未成熟的比格尔犬接受了胸切除术,用西斯普拉丁,多克索鲁比辛或吉姆西塔单方面充肺.
- 肺动脉化疗在隔离肺循环后被注射,停留和吸入.
- 活检和血清样本评估了药物输送和系统性泄漏;动物在手术后的30天内被监测.
主要成果:
- 所有动物都康复了,毒性或并发症的情况最小.
- 血清分析表明,西斯丁和凝丁的系统泄漏率最小,而多克索鲁比辛的水平无法检测.
- 优化的输血剂量显示出最小的毒性,其组织病理学显示局部肺纤维化没有肺外影响.
结论:
- 用思普拉丁,多克索鲁比辛和凝心胺进行肺充血似乎是安全的,并且可用于人体试验.
- 囊泡剂多克索鲁比辛的耐受性低于西斯丁和凝丁,但仍可控.
- 充血技术有效地放大了局部药物输送到肺部,减少了全身毒性.
更多相关视频
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
10.8K
05:11Author Spotlight: Establishing a Murine Non-Small Cell Lung Cancer Model for Developing Nanoformulations of Anticancer Drugs
Published on: May 10, 2024
832
相关概念视频
Flail Chest-II
1.0K
Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
Assessment:
1. Clinical Evaluation:
History:
Assessment:
1. Clinical Evaluation:
History:
1.0K
Pneumothorax-II
1.7K
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
1.7K
Endoscopic Studies II: Thoracocentesis
2.5K
Thoracentesis(Thoracocentesis), commonly known as pleural tap, is a medical procedure where a 22 gauge needle is inserted into the pleural space, the area between the lung and chest wall. This procedure is commonly performed to diagnose or treat various respiratory disorders.
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
2.5K
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
749
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
749
