更年期激素治疗和血清素再吸收抑制剂的影响
Natalia Pereira de Oliveira1, Luciano de Melo Pompei1
1School of Medicine of ABC, Santo André, SP, Brazil.
概括
选择性血红素再吸收抑制剂 (SSRI) 降低了绝经后妇女的唾液流. 激素替代疗法 (HRT) 与口腔干燥的患病率较高有关,尽管唾液流量与对照组相似.
科学领域:
- 口服药是一种口服药.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 绝经后的低雌激素性显著影响口腔健康,影响唾液分泌和炎症过程.
- 更年期期间口腔环境的变化会导致不适和口腔功能变化.
研究的目的:
- 为了比较唾液流速,pH值,以及经更年期妇女接受激素替代疗法 (HRT),选择性血清素再吸收抑制剂 (SSRI) 治疗的口腔干燥 (xerostomia) 的患病率,以及没有接受治疗的妇女.
- 研究不同治疗干预措施对绝经后妇女口腔健康的影响.
主要方法:
- 一项涉及90名绝经后妇女的研究,分为三个组:30名HRT,30名SSRI和30名对照组.
- 唾液流量通过刺激性血清测量,使用pH条的pH水平,通过问卷测量异位菌的流行率.
主要成果:
- 唾液流量在SSRI组 (1.23毫升/分钟) 与HRT (1.66毫升/分钟) 和对照组 (1.68毫升/分钟) 相比显著降低 (p=0.005).
- Xerostomia 的患病率在HRT 组 (60%) 最高,其次是SSRI 组 (46.7%) 和对照组 (26.7%) (p=0.033).
- 唾液pH值在两组之间没有显著差异.
结论:
- 绝经后妇女使用SSRI与唾液流量减少有关.
- 绝经后妇女的激素替代疗法与口腔干燥的发病率较高有关,尽管保持了与未接受治疗的人相比的唾液流量.
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