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Updated: May 14, 2025

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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免疫的先天性错误是大型颗粒性淋巴细胞白血病中克隆性T细胞扩张的基础

Carlos Bravo-Perez1,2, Carmelo Gurnari1,3, Jani Huuhtanen4,5,6,7

  • 1Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.

The Journal of clinical investigation
|May 1, 2025
PubMed
概括

T-LGLL可能是由隐藏的免疫缺陷引起的,而不仅仅是T细胞问题. 这项研究发现,许多患者的基因变异与免疫系统的先天性错误有关,影响了他们的免疫系统和血液细胞计数.

关键词:
适应性免疫是一种适应性免疫.遗传学 遗传学是一种遗传学.血液学 血液学 血液学淋巴瘤是一种淋巴瘤.分子遗传学 分子遗传学

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