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Updated: May 9, 2025

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在β-cateninmRNA的5'UTR中的一个结构元素在缺氧下调节其翻译

Mattia D'Agostino1, Javier Rol-Moreno1,2, Guillaume Bec1

  • 1Architecture et Réactivité de l'ARN, Institut de Biologie Moléculaire et Cellulaire du CNRS, Université de Strasbourg, 2 Allée Konrad Roetgen, Strasbourg 67084, France.

Nucleic acids research
|May 1, 2025
PubMed
概括

在缺氧期间,癌细胞劫持了致癌β-catenin蛋白的翻译. 它的mRNA5'未翻译区域 (5'UTR) 中的一种特定结构驱动了这一过程,为癌症治疗提供了一个新的点.

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