周期性发烧,口腔口炎,喉炎和腺炎综合征:一个更新
Maria Michailou1, Chryssoula Perdikogianni1
1Department of Pediatrics, Medical School University of Crete, 70013 Heraklion, Greece.
Children (Basel, Switzerland)
|May 1, 2025
概括
周期性发烧,口腔口炎,耳炎和腺炎综合征 (PFAPA) 是一种自发炎症性疾病,通常在青春期得到缓解. 这一综述更新了关于PFAPA遗传学及其与其他自身炎症性疾病的联系的知识.
科学领域:
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 周期性发烧,口腔口炎,耳炎和腺炎综合征 (PFAPA) 是一种经常发生的自身炎症性疾病.
- 它通常在童年时呈现出发烧,口腔,喉炎和淋巴腺炎,通常在成年时消失.
- PFAPA被认为是多因素的,受遗传倾向和环境触发因素的影响.
研究的目的:
- 提供关于PFAPA综合征的当前文献的最新评论.
- 专注于了解PFAPA的遗传基础的最新进展.
- 探索PFAPA和其他单一性自身炎症性疾病之间的关联.
主要方法:
- 关于PFAPA的最近研究的文献综述.
- 与PFAPA相关的遗传数据的分析.
- 与其他自身炎症综合征的PFAPA病变发生和治疗的比较.
主要成果:
- PFAPA综合征的特点是经常出现发烧,喉炎,口腔炎和宫淋巴腺炎.
- 虽然在青春期经常自我限制,但有一小部分患者在成年时经历持续的症状.
- 新出现的证据表明,PFAPA和单源性自身炎症性疾病之间在疾病机制和治疗策略方面存在联系.
结论:
- PFAPA综合征仍然是一个具有复杂病因的自身炎症性疾病.
- 对PFAPA遗传学的进一步研究对于了解其病变产生至关重要.
- PFAPA与其他自身炎症性疾病之间的关系为新的治疗方法提供了潜在的见解.
相关概念视频
01:30Acute Pharyngitis
281
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
281
01:23Chronic Pharyngitis
678
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
678
01:30Tonsillitis I: Introduction
186
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
186
01:26Patterns of Fever
2.3K
Before understanding the types and patterns of fever, it is essential to know its phases.
2.3K
01:26Tonsillitis II: Management
96
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
96
01:25Increased Body Temperature
619
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
619