新的系统性炎症指数作为儿童发烧性心肌炎的预测指标
Demet Kangel1, İsa Ozyılmaz1, Sercin Ozkok2
1Division of Pediatric Cardiology, Department of Pediatrics, Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey.
Diagnostics (Basel, Switzerland)
|May 1, 2025
概括
新的全身炎症指数,全身免疫炎症指数 (SII) 和全身炎症反应指数 (SIRI),可以预测儿科心肌炎的不良结果. 这些简单的血液标志物为患有心肌炎的儿童提供了早期预后见解.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 炎症性疾病 炎症性疾病
- 生物标志物发现发现
背景情况:
- 心肌炎是儿童发病率和死亡率的重要原因,可能导致严重的长期心脏并发症.
- 结合淋巴细胞,中性粒细胞和血小板数量的新系统性炎症指数显示出作为预后标记物的前景.
研究的目的:
- 研究新型系统性炎症指数作为儿科心肌炎不良结果的早期预测标记物的实用性.
- 为了比较 fulminant 和 non-fulminant 儿科心肌炎病例之间的这些指数.
主要方法:
- 对122名儿科心肌炎患者 (年龄大于1个月至18岁) 的回顾性分析,诊断时间为2022年1月至2024年12月.
- 将患者分为发性 (需要血液动力学支持) 和非发性组.
- 在诊断后的前6小时内计算和比较系统免疫炎症指数 (SII) 和系统炎症反应指数 (SIRI) 值.
主要成果:
- 这项研究包括122例儿科心肌炎病例;21.3%的患者患有 fulminant心肌炎.
- 与非充剂组 (500) 相比,充剂组 (1300) 的中位数SII显著更高 (p < 0.05).
- 中位数SIRI在充剂组 (2.9) 与非充剂组 (1.5) (p < 0.05) 中也显著更高. 确定了SII和SIRI的截止值,用于预测发性心肌炎.
结论:
- 系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 显示,它们有可能成为儿童不良心肌炎预后的独立预测指标.
- 这些指数很容易从常规血液检查中计算出来,为儿科心肌炎的早期风险分层提供了一种实用的方法.
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