神经类型和神经元的分类 刺激口腔癌的神经元
Cindy G Perez-Pacheco1, Laura A Gonzalez-Maldonado2, Allison Furgal2
1University of Michigan School of Dentistry, Ann Arbor, MI, United States.
概括
口腔状细胞癌 (OSCC) 主要由感觉神经内置,在瘤内增加了感觉和交感神经类型. 这凸显了感官内内在化在OSCC进展和治疗中的关键作用.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 病理学 病理学 病理学
背景情况:
- 神经侵入与口腔状细胞癌 (OSCC) 的低生存率有关.
- 参与OSCC内化的神经的具体类型尚不清楚,这阻碍了机理学和翻译研究.
研究的目的:
- 为了全面描述神经神经神经化类型的人类OSCC.
- 用小鼠模型研究OSCC中感官神经元的作用.
主要方法:
- 免疫组织化学用于识别71个人类OSCC样本中的感觉神经,交感神经和副交感神经.
- 神经元追踪,转录形状分析和转基因小鼠用于研究OSCC中的感官内置.
- 与周围神经侵入 (PNI) 相关的神经类型的分析.
主要成果:
- OSCC主要由感觉神经进行内化,通常与其他类型混合.
- 与边缘相比,瘤体积显示出完全感官和混合感官同情神经的增加.
- 纯感官和混合感官同情神经在PNI+病例中更为普遍.
- 鼠标模型显示,在OSCC中,Calca+ nociceptors的增加和机械受体的减少.
结论:
- 这项研究提供了OSCC中神经类型的第一个详细表征.
- 感官内化,特别是由感觉受体,在OSCC中发挥着重要作用.
- 这些发现对于制定OSCC的向治疗策略至关重要.
相关概念视频
Cranial Nerves: Overview and Anatomy
1.2K
The cranial nerves are an important part of the complex network of nerves in the human body. These nerves emerge directly from the brain and are responsible for transmitting essential information between the brain and various parts of the head and neck. There are 12 pairs of cranial nerves, systematically numbered using Roman numerals from I to XII, beginning from the anterior and moving to the posterior of the brain. Each cranial nerve is uniquely identified by names that reflect its function...
1.2K
Nervous Tissue: Neuron Types
2.1K
Neurons, the fundamental units of the nervous system, can be classified based on both their structural and functional characteristics.
Structurally, neurons are categorized into three main types: multipolar, bipolar, and unipolar (or pseudounipolar). Multipolar neurons, which are the most common type in the brain and spinal cord, as well as all motor neurons, possess multiple dendrites and a single axon.
Bipolar neurons, on the other hand, have one primary dendrite and one axon. They are...
Structurally, neurons are categorized into three main types: multipolar, bipolar, and unipolar (or pseudounipolar). Multipolar neurons, which are the most common type in the brain and spinal cord, as well as all motor neurons, possess multiple dendrites and a single axon.
Bipolar neurons, on the other hand, have one primary dendrite and one axon. They are...
2.1K
Cranial Nerves: Types Part II
1.2K
Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves. While the first six innervate the head and neck, the latter six nerves innervate the head and neck, as well as organs and tissues in the thoracic and abdominal cavities. They facilitate communication, expression, and autonomic control within the human body.
Facial Nerve (Cranial Nerve VII)
Cranial nerve VII, or the facial nerve,...
Facial Nerve (Cranial Nerve VII)
Cranial nerve VII, or the facial nerve,...
1.2K
Cranial Nerves: Types Part I
1.2K
Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves, with the first six being essential in sensory perception, motor control, and autonomic functions related to the head and neck.
Olfactory Nerve (Cranial Nerve I)
The olfactory nerve, or cranial nerve I, is unique as it is purely sensory and dedicated to the sense of smell. This nerve originates in the olfactory epithelium of the...
Olfactory Nerve (Cranial Nerve I)
The olfactory nerve, or cranial nerve I, is unique as it is purely sensory and dedicated to the sense of smell. This nerve originates in the olfactory epithelium of the...
1.2K
Tooth Anatomy
261
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
261
Local Anesthetics: Differential Sensitivity of Nerve Fibers
726
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
726


