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手握强度与慢性病进展之间的关联:从SMP-CKD研究中的见解

Qiong Huang^1,2, Linyi Chen¹, Wenwei Ouyang^3,4

¹The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

International urology and nephrology

|May 1, 2025

概括

较高的手握强度 (HGS) 与中国成年人的慢性病 (CKD) 进展缓慢有关. 保持良好的HGS可以防止功能恶化和脏不良事件.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
老年病的医生老年病的医生
公共卫生公共卫生

背景情况:

慢性病 (CKD) 影响了大部分成年人群,导致功能逐渐丧失.
手握强度 (HGS) 是整体肌肉强度和健康的易于测量的指标.
有限的研究存在于HGS和CKD进展之间的关联,特别是在中国非透析人口中.

研究的目的:

研究手握强度 (HGS) 与慢性病 (CKD) 的进展之间的关系.
评估HGS对中国非透析CKD患者脏终点的影响.
为了确定HGS是否可以作为CKD进展的预后标记.

主要方法:

利用考克斯回归和卡普兰-梅尔生存分析,对来自CKD患者自我管理计划 (SMP-CKD) 队列的数据进行分析.
按性别特定的HGS四分位数,肉症状态分层分析,并通过曲线分析确定HGS值.
比较群体差异,以评估HGS对CKD结果的影响.

主要成果:

在最高HGS四分位数的参与者表现出明显较低的结点风险 (HR 0.102).
缺少肉类与复合CKD结局 (HR 0.422) 和严重结点 (HR 0.265) 的风险较低有关.
性别特定的HGS值 (男性:63.7公斤,女性:34.6公斤) 表明,较高的强度与更好的结局相关.

结论:

手握强度 (HGS) 是预防慢性病 (CKD) 进展的重要保护因素.
较高的HGS水平与非透析CKD患者结点事件的发生率降低密切相关.
HGS作为一个有价值和可访问的生物标志物,用于预测CKD进展和指导患者管理.

关键词:

慢性脏疾病慢性脏疾病手握的强度和握力的强度.萨尔科佩尼亚 (Sarcopenia) 是一个小岛屿.这就是SMP-CKD.

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