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在服用静脉内药物后的非传染性眼内炎症
Karoline E Binder1, Nathalie Bleidißel1, Peter Charbel Issa1
1Department of Ophthalmology, TUM University Hospital, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
JAMA ophthalmology
|May 1, 2025
概括
现实世界的数据显示,对nAMD和DME的静脉注射aflibercept (8mg) 可以导致轻微的眼内炎症 (IOI). 这种炎症随着治疗而消失,最佳校正视敏度 (BCVA) 没有受到影响.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿弗利塞普特 (8毫克) 是一种抗血管内皮生长因子 (VEGF) 疗法,用于治疗新血管与年龄相关的黄斑变性 (nAMD) 和糖尿病黄斑 (DME).
- 临床试验表明,其安全性与阿弗利塞普特 (2毫克) 相似,但需要关于眼内炎症 (IOI) 的真实数据.
研究的目的:
- 为了确定IOI的发病率在临床实践环境下,在静脉内阿弗利伯塞普 (8毫克) 注射后.
- 评估二次结果,包括IOI的时间和最佳校正视敏度 (BCVA) 变化.
主要方法:
- 追溯病例系列分析了为nAMD或DME治疗aflibercept (8毫克) 的患者的病历.
- 纳入标准:在2024年3月至2024年10月期间接受内阿弗利塞普特 (8毫克) 治疗的患者,先前接触过VEGF抑制剂.
- 标准护理包括注射前使用裂光灯检查和注射后4天内进行随访.
主要成果:
- 136次注射给了41名患者 (23人患有nAMD,18人患有DME).
- 5名患者 (12%) 在注射后1-3天内发展出轻度无菌IOI (每注射发生率:3.7%).
- 所有病例都通过抗炎疗法 (局部/副结膜性皮质类固醇,其中2人接受口服皮质类固醇) 而没有影响BCVA.
结论:
- 实际数据表明,与临床试验相比,阿弗利塞普特 (8毫克) 的IOI发病率更高.
- 观察到的IOI病例是轻微的,通过治疗有效地解决,并没有导致视力丧失.
- 这些发现强调了在临床实践环境中对IOI的监测的重要性.
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