相关实验视频
Updated: Jul 13, 2026
07:42
A High-Throughput Platform for Culture and 3D Imaging of Organoids
Published on: October 14, 2022
2.4K
人体器官作为基因组查的新兴工具
Francesco Andreatta1, Delilah Hendriks1, Benedetta Artegiani1
1Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands; email: d.f.g.hendriks-7@prinsesmaximacentrum.nl, b.a.artegiani@prinsesmaximacentrum.nl.
Annual review of biomedical engineering
|May 1, 2025
概括
在有机体中的CRISPR-Cas选正在彻底改变人类生物学研究. 本综述探讨了这些强大的基因编辑工具在有机模型中的策略,挑战和发现.
科学领域:
- 生物技术是生物技术.
- 基因组学就是基因组学.
- 发展生物学 发展生物学
背景情况:
- 器官模型回顾了人类的发育,疾病和组织修复.
- 器官体是从组织干细胞或多能干细胞 (PSC) 衍生出来的.
- 克里斯普尔-卡斯基因编辑已经推进了有机体研究.
研究的目的:
- 审查基于CRISPR的查在有机体中的适应性.
- 检查有机体中CRISPR查的策略,范围和读数.
- 突出挑战,并讨论从有机基因组选研究的发现.
主要方法:
- 关于有机体中CRISPR查的最新文献的综述.
- 分析执行CRISPR选的策略 (例如,范围,读取).
- 讨论特定于有机体平台的挑战.
主要成果:
- 在有机体中进行的CRISPR选发现了各种生物过程中的新基因.
- 该审查审查了这些查的不同方法和结果.
- 讨论了在实施CRISPR查方面面临的器官特异性挑战.
结论:
- 在有机体中进行CRISPR查是了解人类生物学的一个强大工具.
- 广泛采用可以显著推进该领域.
- 未来的展望侧重于利用这些技术来获得更深入的生物学见解.
更多相关视频
相关概念视频
00:49What is Genetic Engineering?
Overview
02:54Evolutionary Relationships through Genome Comparisons
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
03:36Genome Annotation and Assembly
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
02:46Genetic Screens
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
01:28Human Genetics
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...