冠状病毒疾病2019年 (COVID-19) 疫苗接种和自发流产
Sangini S Sheth1, Gabriela Vazquez-Benitez, Malini B DeSilva
1Yale School of Medicine, New Haven, Connecticut; HealthPartners Institute, Bloomington, Minnesota; the Institute for Health Research, Kaiser Permanente Colorado, and Ambulatory Care Services, Denver Health, Denver, Colorado; Kaiser Permanente Southern California, Pasadena, and Kaiser Permanente Vaccine Study Center, Oakland, California; Kaiser Permanente Center for Health Research, Portland, Oregon; Kaiser Permanente Washington Health Research Institute, Seattle, Washington; Marshfield Clinic Research Institute, Marshfield, Wisconsin; the Immunization Safety Office, Centers for Disease Control and Prevention, Atlanta, Georgia; and Weill-Cornell School of Medicine, New York, New York.
怀孕期间的COVID-19疫苗接种与自发流产没有关联. 这项研究支持COVID-19疫苗在怀孕早期的安全性,为准孕妇提供了保证.
科学领域:
- 生殖健康 生殖健康
- 疫苗安全问题 疫苗安全问题
- 流行病学 流行病学
背景情况:
- 怀孕期间接种2019年新冠病毒病 (COVID-19) 疫苗的安全性存在担忧.
- 自发流产是孕妇的一个重大问题.
研究的目的:
- 为了调查COVID-19疫苗接种和自发堕胎之间的潜在关联.
- 为了评估在怀孕早期服用的COVID-19疫苗的安全性.
主要方法:
- 使用来自疫苗安全数据链接 (VSD) 网站的数据进行了一项病例控制研究.
- 符合条件的参与者包括16-49岁的女性,单胎怀孕经历了自发流产或活产.
- 使用条件后勤回归来分析疫苗接种与自发流产之间的关联,并根据剂量,制造商和时间进行二次分析.
主要成果:
- 这项研究包括296例自发流产和592例活产对照.
- 在COVID-19疫苗接种和自发流产之间没有发现统计学意义上的关联 (aOR 0.85,95% CI,0.56-1.30).
- 进一步的分析显示,与剂量数,疫苗制造商 (Moderna,Pfizer-BioNTech) 或在事件发生后6周内接种疫苗相关的风险没有增加.
结论:
- 研究结果表明,在怀孕期间接种COVID-19疫苗和自发流产之间没有观察到关联.
- 这些结果支持怀孕早期COVID-19疫苗接种的安全性.
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