一个便携式的汗水生物传感器用于多种慢性病的生物标志物检测
Ping Gao1, Yan Liu2, Jing Sun1
1School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Jilin Provincial Science and Technology Innovation Center of Optical Materials and Chemistry, Jilin Provincial International Joint Research Center of Photo Functional Materials and Chemistry, Changchun, 130022, People's Republic of China.
Talanta
|May 1, 2025
概括
一个新的便携式生物传感器可以在汗水中持续,非侵入性地监测慢性病 (CKD) 的关键生物标志物. 这一进步有望改善对慢性病患者的临床诊断和个性化管理.
科学领域:
- 电化学 电化学 电化学
- 生物传感器技术技术
- 生物标志物检测检测 生物标志物检测
背景情况:
- 慢性病 (CKD) 管理需要持续监测毒素生物标志物.
- 目前用于CKD的汗水分析方法缺乏灵敏度,特异性和耐用性.
- 非侵入性检测方法对于患者的方便和积极的疾病管理至关重要.
研究的目的:
- 开发一种新的分子印记便携式生物传感器,用于同时检测人汗中的尿素,肌素和尿酸.
- 克服传统生物传感器的局限性,包括灵敏度,特异性和长期稳定性.
- 提供一个方便和准确的工具,用于诊断和个性化管理CKD.
主要方法:
- 在PET薄膜上制造一个灵活的生物传感器,使用印技术.
- 开发三元复合电极 (NiCoMOF/MWCNTs/NCDs) 以提高电化学性能.
- 应用分子印记技术,为目标生物标记物创建特定的识别腔.
主要成果:
- 生物传感器表现出高灵敏度和低检测限值的尿素,肌素和尿酸.
- 在各种生理度范围内实现了优异的线性 (R2 > 0.995).
- 在60天后,信号保留率维持在95.8%以上,表明长期耐用性.
- 在汗水样本中成功执行了三种生物标志物的同步动态监测.
结论:
- 开发的分子印记便携式生物传感器为非侵入性CKD生物标志物监测提供了有前途的解决方案.
- 这项技术可实现连续,方便和准确的护理点诊断.
- 生物传感器在慢性病中具有个性化管理策略的巨大潜力.
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