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间歇性肺病和非小细胞肺癌患者的辐射毒性和生存率:一个病例对照研究
Aurélien Justet1, Léonard Jackson2, Matthieu Bardon3
1Service de pneumologie et oncologie thoracique, centre hospitalier universitaire de Caen, Caen, France; Unicaen, CEA, CNRS, ISTCT Group, GIP Cyceron, université de Normandie, Caen, France.
概括
间歇性肺病 (ILD) 影响7%的接受放射治疗的肺癌患者. 那些患有ILD的人面临更高的毒性风险和更差的生存结果,需要仔细评估肺部和量身定制的治疗策略.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 辐射疗法 辐射疗法
背景情况:
- 间歇性肺病 (ILD) 复杂化了肺癌的管理.
- 在ILD患者的胸部放射治疗提出了独特的挑战.
- 在被照射的肺癌患者中,ILD的患病率,耐受性和预后需要进行调查.
研究的目的:
- 在接受放射治疗的肺癌患者中确定间歇性肺病 (ILD) 的患病率.
- 评估肺癌患者的耐受性和临床结果,包括ILD后胸部放射治疗和没有ILD的患者.
主要方法:
- 一个双中心的病例控制研究设计.
- 包括连续照射的非小细胞肺癌患者 (2018年1月 - 2020年12月).
- 对CT扫描,功能评估,毒性评估和生存分析的集中审查.
主要成果:
- 在7.2%的患者中发现了间歇性肺病 (ILD).
- 患有ILD的患者出现2级以上肺炎 (41.7%对11%) 和住院治疗 (16%对2%) 的比率显著更高.
- 在ILD组观察到的结果较差:客观反应较差,无进展生存时间较短 (9.35与18.56个月),总生存时间减少 (17个月与未达到).
结论:
- 间歇性肺病 (ILD) 存在于接受放射治疗的肺癌患者中显著的百分比.
- ILD显著增加严重毒性的风险,并对预后产生负面影响.
- 放射治疗前对ILD的评估和制定特定的管理方案对于改善患者的治疗结果至关重要.
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