YAP表达与牙产生的囊的侵略性行为有关
Jutamas Uttagomol1, Adjabhak Wongviriya1, Ariya Chantaramanee2
1Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand.
European journal of dentistry
|May 1, 2025
概括
在牙发作性囊中评估了YAP和Ki-67表达. 牙发育性角质囊显示出较高的YAP和Ki-67水平,这表明这些囊在增殖行为中发挥了作用.
科学领域:
- 口腔病理学 口腔病理学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 是的相关蛋白 (YAP) 和Ki-67是细胞增殖的关键调节者.
- 过度表达YAP和Ki-67与侵袭性口腔状细胞癌 (OSCC) 有关.
- 它们在牙发作性囊中的特定作用仍未得到充分研究.
研究的目的:
- 通过免疫组织化学评估YAP和Ki-67在各种牙产生的囊中的表达.
- 为了比较不同囊类型和正常口腔粘膜之间的YAP和Ki-67表达水平.
- 探索YAP和Ki-67在牙发育性囊中的潜在相关性.
主要方法:
- 对YAP和Ki-67表达的免疫组织化学分析在12个根性囊,10个牙状囊,9个口腔质囊和9个正常口腔粘膜样本中.
- 使用ImageJ软件进行定量分析.
- 使用克鲁斯卡尔-瓦利斯和曼-惠特尼U测试进行统计评估,与蛋白质关联的斯皮尔曼相关性 (p < 0.05).
主要成果:
- 与根性囊,牙状囊和正常口腔粘膜相比,Odontogenic keratocysts表现出明显更强的核和细胞质YAP染色 (p <0.05).
- 与其他囊类型和正常的口腔粘膜相比,ki-67的表达在牙发生性角质囊中明显增加.
- 在所有组中都没有发现YAP和Ki-67之间有显著的相关性,但在牙生囊中观察到积极的趋势.
结论:
- YAP的激活似乎与牙发作性囊的增殖潜力有关,特别是在像牙发作性角质囊这样的侵略性类型中.
- YAP不太可能是炎症性牙发作性囊的病变发生的一个重要因素.
- 这些发现可能有助于更好地了解牙发作性囊的病原性,并为未来的诊断和治疗策略提供信息.
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