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血蛋白质组与心声回声学参数和扩张功能障碍的阶段有关,在整个喷射分数谱中

Sabrina Abou Kamar¹, Anne-Mar van Ommen², Elisa Dal Canto³

¹Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Cardiology, Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands.

International journal of cardiology

|May 1, 2025

概括

这项研究揭示了与心力衰竭 (HF) 亚型和腹功能障碍相关的独特血蛋白质概况. 这些发现提供了关于HFpEF和HFrEF背后的不同生物机制的见解.

科学领域:

心血管医学心血管医学
蛋白质组学是指蛋白质组学.
生物标志物发现发现

背景情况:

研究了循环等离子体蛋白与心力衰竭 (HF) 中心声心脏学测量之间的关系.
涵盖HF的范围,包括心力衰竭与保留喷射率 (HFpEF) 和心力衰竭与减少喷射率 (HFrEF).

研究的目的:

探索不同HF亚型的血蛋白质和心声回声学参数之间的相互作用.
为了识别与左心室喷射分数 (LVEF) 和腹功能障碍相关的蛋白质生物标志物.

主要方法:

通过使用 SomaScan® 蛋白质组学分析了两组 (HELPFul 和 Bio-SHiFT) 750 名患者的血蛋白质组数据.
测量了4210个循环等离子体蛋白,并评估了心声学参数,包括LVEF和E/e'比率.
将患者分类为左心室扩张功能障碍 (LVDD) 组.

主要成果:

确定了21种与HFpEF中的E/e'相关的蛋白质,以及9种与LVEF相关的蛋白质.
43%的蛋白质显示了E/e'和HF亚型之间的显著相互作用,与HFrEF相比,HFpEF的关联较弱.
发现了40种与2级LVDD相关的蛋白质和198种与3级LVDD相关的蛋白质,包括NT-proBNP和Cystatin C.

结论:

在HFpEF中,生物途径与E/e'的关联比HFrEF更弱.
蛋白质组路径与LVDD在射出分数谱中的进展有关.
这些发现与当前HF亚型的机制框架保持一致.

关键词:

扩张性功能障碍扩张性功能障碍 E/e E/e E/e E/e E/e E/e E/e E/e E/e E/e 心声回声扫描 (Echocardiography) 是一种心声回声扫描.心脏衰竭是因为心脏衰竭.蛋白质组学是指蛋白质组学.

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