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阿格里莫尼亚罗萨提取物通过调节PI3K/AKT/Bcl-2通路来抑制NSCLC的生长

Ze-Hua Tong¹, Wen-Jun Guo², Ya-Juan Xu²

¹School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, 130117, PR China.

Journal of ethnopharmacology

|May 1, 2025

概括

阿格里莫尼亚草提取物 (APE) 通过诱导亡和改变新陈代谢来对抗非小细胞肺癌. 它针对PI3K/AKT/Bcl-2通路,对关键的亡标志物进行上调,并影响TCA循环等代谢通路.

科学领域:

在瘤学瘤学.
药理学药理学是一个学科.
代谢学代谢学代谢学

背景情况:

阿格里莫尼亚草提取物 (APE) 是一种具有抗炎和止血功能的传统中医药.
APE用于癌症治疗,包括肺癌,但其在非小细胞肺癌 (NSCLC) 中的分子机制尚未完全理解.

研究的目的:

研究在NSCLC细胞中APE诱导的亡的分子机制.
评估APE对NSCLC细胞代谢的影响.

主要方法:

用小鼠移植瘤模型来评估APE的抗瘤作用.
基于液态染色体质谱学 (LC-MS) 的非向代谢分析分析了血清和瘤组织代谢物.
西部涂抹 (WB) 和RT-qPCR验证了信号通路中的关键蛋白质和基因.

主要成果:

通过促进亡和改变新陈代谢,APE抑制了瘤的生长.
APE降低了PI3K/AKT/Bcl-2通路的调节,并提高了细胞亡标记物的调节 (TP53,Bax,Caspase-3,Cytochrome c).
代谢学发现了120种不同的代谢物,揭示了APE对糖脂代谢,氨基酸代谢和TCA循环的调节.

结论:

通过调节PI3K/AKT/Bcl-2通路和代谢通路,APE诱导亡并抑制NSCLC的生长.
这项研究增强了对APE在NSCLC中的抗癌机制的理解,为进一步研究提供了基础.

关键词:

在A549细胞.这是Agrimonia pilosa的提取物.细胞灭亡 (apoptosis) 是一种死亡的过程.代谢学代谢学代谢学通过PI3K/AKT/Bcl-2路径.

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