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相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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RNA Splicing01:32

RNA Splicing

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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相关实验视频

Updated: May 23, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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在精神分裂症中长非编码RNA.

Seyyed Navid Mousavinejad1, Seyed Ali Hosseini2, Mozhdeh Mohammadpour3

  • 1Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Clinica chimica acta; international journal of clinical chemistry
|May 1, 2025
PubMed
概括

长非编码RNAs (lncRNAs) 是精神分裂症的关键参与者,影响基因表达和神经发育. 患者的lncRNA水平变化表明它们有可能成为这种复杂的大脑疾病的诊断生物标志物.

关键词:
生物标志物 生物标志物神经发育过程 神经发育过程精神分裂症是一种精神分裂症.在 lncRNAs 中.

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.
  • 分子生物学分子生物学

背景情况:

  • 精神分裂症是一种复杂的神经精神疾病,具有遗传和环境影响.
  • 长非编码RNAs (lncRNAs) 越来越多地被认为是疾病发病的关键调节者.
  • 在精神分裂症患者的血液和脑组织中观察到异常的lncRNA表达.

研究的目的:

  • 审查目前对 lncRNAs 在精神分裂症中的作用的理解.
  • 突出 lncRNAs 在精神分裂症的诊断潜力.
  • 探索 lncRNAs 作为潜在的治疗点.

主要方法:

  • 关于 lncRNAs 和精神分裂症的研究的文献综述.
  • 在患者样本中分析lncRNA表达特征.
  • 在神经生物学途径中研究 lncRNA 机制.

主要成果:

  • 在精神分裂症中,特定的lncRNAs (Gomafu,DISC-2,BDNF-AS,MEG3,TUG1) 的调节失调.
  • lncRNAs影响神经发育,炎症和突触可塑性.
  • 抗精神病治疗影响lncRNA的表达,与症状改善相关.
  • 在 lncRNA 调节中注意到性别特异性和年龄相关的差异.

结论:

  • lncRNAs在精神分裂症病理生理学方面具有重要意义.
  • 改变的lncRNA表达具有作为诊断生物标记物的前景.
  • lncRNAs代表了新型精神分裂症治疗策略的潜在目标.