相关实验视频

Updated: May 9, 2025

Production of Human Neurogenin 2-Inducible Neurons in a Three-Dimensional Suspension Bioreactor

Production of Human Neurogenin 2-Inducible Neurons in a Three-Dimensional Suspension Bioreactor

Published on: March 17, 2023

生物技术方法用于生产神经活性的huperzine A

Mubeen Fatima¹, Phetcharat Boonruamkaew², Mengquan Yang³

¹School of Pharmacy, Walailak University, Thasala, Nakhon Si Thammarat 80160, Thailand; College of Graduate Studies, Walailak University, Thasala, Nakhon Si Thammarat 80160, Thailand.

Journal of biotechnology

|May 1, 2025

概括

胡氨酸A通过抑制乙胆酶,对神经退行性疾病具有前景. 研究探索可持续生产方法,如生物技术,以满足治疗需求.

科学领域:

药理学和神经科学药理学和神经科学
生物技术和合成生物学

背景情况:

胡素A (HupA) 是一种天然的化物,具有证明的神经保护作用.
它通过抑制乙胆酶和调节神经路径来起作用,显示出各种神经退行性疾病的潜力.

研究的目的:

审查Huperzine A对神经退行性疾病的治疗潜力.
探索生物技术策略,以提高Huperzine A的生产,由于有限的自然产量.

主要方法:

在体外,体内和临床数据的综合文献调查.
对HupA生产的化学合成,微生物发酵,植物组织培养和合成生物学进行分析.
讨论关键的生物合成酶和代谢工程方法.

主要成果:

HupA对阿尔茨海默氏症,帕金森症,亨廷顿病,多发性硬化症,和肌痛性硬化症具有治疗潜力.
生物技术方法为HupA生产提供了可扩展和可持续的替代天然提取方法.
阐明代谢途径和工程对于优化HupA生物合成至关重要.

结论:

胡素A是一种有前途的神经治疗药物,用于治疗多种神经退行性疾病.
生物技术生产的进步对于满足临床需求和实现广泛的治疗用途至关重要.
将HupA整合到治疗策略中,在创新生产的支持下,可以显著改善神经退行性疾病的管理.

关键词:

这种植物叫Huperzia carinata.这种植物叫Huperziaceae.这种药物是Lycodane.这种植物属于Lycopodiaceae.弗莱格玛林 (Phlegmarine) 是一种的药物.弗莱格马里乌鲁斯 (Phlegmariurus) 是一个鱼.

更多相关视频

GM-Free Generation of Blood-Derived Neuronal Cells

GM-Free Generation of Blood-Derived Neuronal Cells

Published on: February 13, 2021

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons

Published on: July 11, 2020

相关概念视频

Drugs Affecting Neurotransmitter Synthesis

Drugs Affecting Neurotransmitter Synthesis

Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...