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对心血管疾病的性别特异性MSC疗法的科学测量分析

Elika Verma¹, Mehak Gupta¹, Riley Sierhuis¹

¹Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre Regenerative Medicine Program, Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Biomedical Engineering Program, University of Manitoba, Winnipeg, Manitoba R2H2A6, Canada.

Biochimica et biophysica acta. Molecular basis of disease

|May 1, 2025

概括

对心血管疾病中介质干细胞 (MSC) 治疗的研究越来越多地关注性别特异性差异. 这一转变凸显了基于男性和女性生物差异的个性化治疗的必要性,以改善结果.

科学领域:

心血管再生医学心血管再生医学
干细胞生物学干细胞生物学
性别特定的研究.

背景情况:

介质细胞干细胞 (MSC) 疗法对心血管疾病具有前景.
在MSC治疗中,性别特异性的差异仍未得到充分研究.
这种科学度分析提供了1947-2024年研究趋势的历史概述.

研究的目的:

综合分析心血管疾病MSC治疗中的性别特异性差异.
确定研究热点,出版趋势和协作网络.
为了了解研究重点随着时间的推移的演变.

主要方法:

对61,029个出版物的图书统计分析.
使用了先进的文献计量工具和VOSviewer.
识别了关键词集群和网络可视化.

主要成果:

在21世纪,研究重点从一般的心血管概念转移到性别特定的考虑.
显而易见的男性和女性研究集群出现,表明越来越多的人认识到性别差异.
与性别特异性相关的关键词,如"遗传关联"和"体重指数",形成了不同的集群.

结论:

性别特定的考虑对于心血管疾病中MSC治疗至关重要.
根据性别差异量身定制方法是必不可少的,正如不同的研究集群所证明的那样.
未来的研究应该探索表观遗传学和性别匹配的MSC衍生的外体,以实现个性化的心血管再生医学.

关键词:

心血管疾病是什么心血管疾病介质细胞干细胞介质细胞干细胞科学测量分析的科学测量分析性爱性的性爱性的性爱

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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...