在妊娠后期与母亲肠道微生物组合相关的产前PFAS暴露和结果
Stephanie Morgan1, Sayed Hassan Raza Shah2, Sarah S Comstock3
1Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, 48202, USA.
Environmental research
|May 1, 2025
概括
怀孕期间暴露于per-和多醇基物质 (PFAS) 与母亲肠道微生物组的变化有关. 这些关联是在两个不同的队列中观察到的,这表明PFAS可能会调节肠道细菌的组成.
科学领域:
- 环境健康 环境健康
- 微生物组研究 微生物组研究
- 毒理学 毒理学 毒理学
背景情况:
- 肠道微生物组的组成受到饮食,生活方式和化学物质暴露的影响.
- 和多基基物质 (PFAS) 是人造化学物质,具有潜在的健康影响.
- 了解环境化学物质对母亲微生物群的影响对于儿童健康至关重要.
研究的目的:
- 调查 PFAS 产前暴露与母亲肠道微生物组之间的关联.
- 在"环境影响儿童健康结果" (ECHO) 计划中,分析两个地理不同群体中的这些关联.
主要方法:
- 对来自孕妇的母体肠道微生物组样本的血清/血PFAS度和16S rRNA测序的分析.
- 使用线性回归,贝叶斯核机器回归和弹性网回归混合模型.
- 调整了包括饮食,年龄,种族,BMI和吸烟在内的共同变量.
主要成果:
- 多个PFAS与两个队伍中特定肠道细菌种类的相对丰富程度有显著的关联.
- 确定了重要的家族层面的关联,例如,PFOA与Clostridiaceae在一个队列中,PFOS与Desulfovibrionaceae在另一个队列中.
- PFAS和肠道微生物组组成之间的关联是队列特异性的,两组之间的相似性有限.
结论:
- 产前暴露于PFAS与母亲肠道微生物组合的改变有关.
- 观察到的对肠道微生物群的影响似乎是群体特有的.
- 需要进一步的研究来了解PFAS在怀孕期间可能调节肠道微生物群的机制.
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