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肺部立体体射线疗法使用动态合体弧疗法,带有或没有平面化波器光子束 - - 法国机构的经验

Mickael Preault¹, Leonor Chaltiel², Jonathan Khalifa¹

¹Radiation Department, Institut Claudius Regaud, IUCT-O, Toulouse, FRANCE.

Practical radiation oncology

|May 1, 2025

概括

无平过器 (FFF) 辐射疗法对肺部瘤是安全有效的,提供了与平过器 (FF) 技术相比较的优秀局部控制. 这种先进的方法保证了低毒性和可比的存活率在体内立体辐射疗法.

科学领域:

辐射瘤学辐射瘤学
医学物理医学物理

背景情况:

立体体辐射疗法 (SBRT) 是肺瘤的关键治疗方法.
辐射输送技术的进步旨在提高疗效和患者安全.

研究的目的:

为了比较无平面化镜 (FFF) 与平面化镜 (FF) 技术在肺部SBRT中的安全性和有效性.
评估两种技术之间的局部控制,生存和毒性.

主要方法:

在82名患者中对101例肺SBRT治疗进行了回顾性分析.
使用一致的分割协议,比较FF (n=47) 和FF (n=54) 技术.
动态符合性半弧治疗计划,剂量按80%的异位剂量线规定.

主要成果:

优秀的两年地方控制率 (97.9%的FFF对比98.1%的FFF).
观察到低毒性,在4.1%的FF患者中出现3级肺毒性,而在FFF患者中没有.
在两组之间,症状性肋骨骨折率相似 (3 FFF与1 FF).

结论:

使用FFF技术的肺部SBRT是安全的,并实现了优秀的长期局部控制.
在肺SBRT中,FFF技术表现出与FFF技术相似的疗效和低毒性.
由于更高的剂量率,FFF提供更快的治疗交付.

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