益生菌,益生菌或共生菌在硬化肌病中的疗效:系统性审查
Adam A Wach1, Dawid Storman2, Krzysztof Więckowski1
1Students' Scientific Research Group, Systematic Reviews Unit, Jagiellonian University Medical College, Krakow, Poland.
益生菌仅有有限的证据表明,它可以改善硬化皮质症的症状,但对胃肠道问题和生活质量的影响尚不确定. 为了得出最终的结论,需要对特定菌株和较低偏差进行进一步研究.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 微生物组研究 微生物组研究
背景情况:
- 系统性硬化皮肤病原是复杂的,有可能涉及肠道微生物群.
- 益生菌被用于自身免疫性疾病,但对硬化硬质皮的证据有限且未被评估.
- 对于益生菌在硬化皮肤病管理中的使用,目前还没有官方建议.
研究的目的:
- 评估益生菌,益生菌或共生菌在硬化肌病患者的疗效.
- 评估症状的改善,生活质量 (QoL) 和小肠细菌过度生长 (SIBO).
- 检查对间歇性肺病和肺高血压的影响.
主要方法:
- 系统性搜索随机对照试验 (RCT) 的前,前,和共生药在硬化皮肤病.
- 独立研究选择,数据提取和偏差风险 (RoB) 评估.
- 使用GRADE方法评估的证据确定性.
主要成果:
- 包括4个RCT,共210名参与者.
- 益生菌摄入量显示,对于改善胃肠道症状的证据确定性低至非常低.
- 观察到社会功能略有改善,但对身体功能,生活质量和SIBO的影响尚不确定.
- 没有研究涉及对间歇性肺病或肺高血压的影响.
结论:
- 目前的证据不足以证实益生菌在硬化皮肤病中的积极或负面影响.
- 低至非常低的证据确定性需要谨慎的解释.
- 需要进一步进行高质量的,具有减少RoB的菌株特异性RCT.
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