以阿雅华斯卡为灵感的DMT/HAR配方减少了大脑在自我和其他面孔之间的分化
Dila Suay1, Helena D Aicher2, Micheal Kometer3
1Momilab, IMT School for Advanced Studies, Lucca, Italy; Department of Adult Psychiatry and Psychotherapy, Psychiatric University Clinic Zurich and University of Zurich, Switzerland.
NeuroImage
|May 1, 2025
概括
像DMT/HAR这样的迷幻药物通过破坏早期视觉处理和减少自我与其他面孔之间的神经区别来改变面部识别. 这表明,对于涉及刚性自我焦点的疾病,这可能有潜在的治疗益处.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 认知科学 认知科学
背景情况:
- 迷幻药物深刻地改变了感知和自我参考处理.
- 它们对面部识别,特别是熟悉度的具体影响尚未得到充分研究.
研究的目的:
- 调查DMT/HAR和Harmine对人脸识别和自我参考处理的影响.
- 利用与事件相关的潜力 (ERP) 和主观措施.
主要方法:
- 在主体内,双盲,安慰剂控制的设计与30名健康男性.
- 在视觉奇怪任务中对自我,熟悉和未知的面孔进行EEG记录.
- 对比DMT/HAR,Harmine和安慰剂对P1,N170和P300ERP组件的影响.
主要成果:
- DMT/HAR增加了P1和减少了N170的幅度,表明早期视觉处理发生了改变.
- 在P300波中,DMT/HAR减少了自我与其他面孔之间的神经分化.
- 熟悉的面部处理保持稳定,保留了具有社会意义的表征.
结论:
- DMT/HAR选择性地减弱了自我与其他面孔之间的神经区分,与减少的自我参考处理相关.
- 这突出了人脸识别和迷幻诱导的神经重组的血清调节.
- 减少自我-其他差异化可能会增强认知灵活性,为抑郁症和社会焦虑症提供治疗潜力.
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