通过喷雾干燥使用纤维素基聚合物进行乳酸菌植物菌的微封装:一种益生菌输送系统,可增强抗酸性和储存稳定性
Danial Gazalian1, Atousa Aliahmadi2, Hasan Rafati1
1Department of Pharmaceutical Engineering, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran.
概括
用纤维素基聚合物,如高烯酸酸盐 (HPMCP) 微封装Lactobacillus plantarum显著提高了在喷雾干燥和胃肠道过境期间的益生菌生存率,创造了更强大的益生菌产品.
科学领域:
- 食品科学与技术 食品科学与技术
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
背景情况:
- 益生菌的活力对疗效至关重要,但在加工和消化过程中经常受到损害.
- 纤维素衍生物由于其薄膜形成和可调节性质,具有保护性微封装的潜力.
研究的目的:
- 为了评估高糖甲酸盐 (HPMCP) 和HPMCP/高糖 (HPMC) 混合物作为Lactobacillus plantarum微封装的涂层.
- 评估这些纤维素基涂料在喷雾干燥,储存和模拟胃肠道条件期间对益生菌生存的影响.
主要方法:
- 使用HPMCP和HPMCP/HPMC混合物进行乳酸菌植物菌的微封装.
- 微囊的物理化学特性 (SEM,FT-IR,DSC) 的表征.
- 在喷雾干燥后,在12周的储存期间以及在模拟的胃和肠液 (SGF/SIF) 中评估细胞活力.
主要成果:
- 喷雾干燥的生存率从78.33% (自由细胞) 增加到91.59% (HPMCP) 和94.27% (HPMCP/HPMC).
- 微囊在12周内保持了>10^9 CFU/g的活力,并且在SGF中显著减少了细胞损失 (0.34-0.8日志CFU/g对比自由细胞的3.36日志CFU/g).
- SEM证实了成功的封装,FT-IR表明了聚合物相互作用,DSC显示了玻璃过渡温度 (Tg) 的增加,从而提高了矩阵刚性.
结论:
- 基于纤维素的聚合物 (HPMCP和HPMCP/HPMC) 在加工和模拟消化过程中有效地保护乳酸菌.
- 这些微封装策略增强了益生菌的稳定性,为改善口服和产品开发提供了潜力.
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