微生物群中的食纤维反应揭示了疾病特异性益生菌方法的机会
T Chen1,2, T M Cantu-Jungles2, B Zhang2,3
1State Key Laboratory of Food Science & Technology, School of Food Science & Technology, Nanchang University, 235 East Nanjing Road, Nanchang 330047, P.R. China.
Beneficial microbes
|May 1, 2025
概括
食纤维 (益生菌) 对肠道细菌的影响因克罗恩病,性结肠炎和帕金森病等健康状况而异. 根据特定疾病量身定制益生菌选择可以优化肠道微生物群的反应,以获得更好的健康结果.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 益生菌或可发酵食纤维因其调节肠道微生物群落的能力而得到认可.
- 这些纤维有潜力管理与各种疾病相关的失生状态.
- 然而,肠道微生物群对不同健康状况的纤维干预的差异反应仍然不太清楚.
研究的目的:
- 研究肠道微生物群对不同饮食纤维在不同健康状况中的机械反应.
- 为了比较纤维发酵对健康对照组 (HC),克罗恩病 (CD),性结肠炎 (UC) 和帕金森病 (PD) 患者肠道微生物群的影响.
主要方法:
- 在体外便发酵试验中,使用各种食纤维进行了测试.
- 使用来自HC,CD,UC和PD个体的便微生物群落.
- 量化了短链脂肪酸 (SCFA) 产量,并通过16S rRNA基因安普利康序列分析了微生物社区结构转变.
主要成果:
- 所有测试的食纤维都增强了SCFA的产生,根据疾病状态和纤维类型观察到的变化.
- 在发酵后微生物群落结构转移的程度在各种条件上有显著差异.
- 患有UC的个体表现出较弱的反应,而患有PD的个体表现出显著的微生物变化.
- 特定的纤维类型在调节微生物结构和促进每个健康状况的SCFA方面表现出卓越的疗效.
结论:
- 肠道微生物群对食纤维的反应是疾病特异性的.
- 通过将纤维选择量身定制为个人健康状况,可以优化益生菌干预措施的有效性.
- 这表明,在各种疾病中,使用益生菌来管理肠道失生症是一种个性化的方法.
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