在帕金森病中开发用于食障碍干预的核心结果集:国际德尔菲共识研究研究
Julia Hirschwald1, Paul Conroy2, Gary Boyle2
1Department of Clinical Speech and Language Studies, Trinity College Dublin, Dublin, Ireland hirschwj@tcd.ie.
BMJ evidence-based medicine
|May 1, 2025
概括
为帕金森病的口腔喉乱干预开发了一套核心结果. 这种标准化的方法确保了一致的结果测量,以改善研究和患者护理.
科学领域:
- 神经学 神经学
- 临床试验 临床试验
- 语音语言病理学 语音语言病理学
背景情况:
- 口腔喉乱是帕金森病的常见和衰弱的症状.
- 在帕金森病的临床试验中缺乏标准化结果测量.
- 需要一个以共识为导向的核心成果集 (COS),以提高研究可比性.
研究的目的:
- 在帕金森病中建立口腔喉乱干预的COS.
- 在核心成果,其定义和测量仪器上达成一致.
- 确保对未来研究的结果评估的相关性和一致性.
主要方法:
- 国际在线Delphi调查与关键利益相关者.
- 达成共识的会议最终确定了核心成果和测量参数.
- 利用了涉及帕金森病患者,护理人员和临床医生的多阶段过程.
主要成果:
- 确定了六个核心结局:透/吸入,吸入性肺炎,窒息,消化不良严重程度,生活质量和喉残留.
- 在这些结果的定义和测量工具上达成共识.
- 来自21个国家的90名参与者参与了德尔菲调查.
结论:
- 开发的COS将在帕金森病失试验中标准化结果报告.
- 促进比较有效性研究,并增强干预措施的证据基础.
- 确保研究成果对患者,临床医生和研究人员有意义.
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