在过去两年内因各种急性疾病住院治疗与老年人的认知能力下降有关:悉尼记忆和衰老研究
Lucia Chinnappa-Quinn1,2, Ben C P Lam1,3, Lara Harvey4,5
1Centre for Healthy Brain and Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, UNSW, Sydney, Australia.
International journal of geriatric psychiatry
|May 1, 2025
概括
急性住院加快了老年人的认知衰退,最近入院的影响更大. 这表明住院是认知障碍的可逆风险因素.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 新出现的证据将所有原因的急性住院病例与认知衰退联系起来.
- 这种关联可能超出特定的背景,如手术或妄想.
- 了解这种关系对于管理老年人群的认知健康至关重要.
研究的目的:
- 调查澳大利亚队伍中急性住院和认知衰退之间的关联.
- 为了确定住院病例和累积住院时间 (cLOS) 是否会随着时间的推移影响全球认知功能.
- 探索住院治疗对认知轨迹的剂量依赖和近期影响.
主要方法:
- 来自悉尼记忆和衰老研究的前性,基于人口的数据的二次分析.
- 包括1026名70-90岁的功能独立参与者.
- 连接神经心理测量与住院数据,跨越5个2年间隔超过10年.
主要成果:
- 在最后一段时间内住院和cLOS与加速的全球认知衰退显著相关.
- 每次住院/年与认知z-score/年变化为-0.012,每天住院/年变化为-0.002有关.
- 最近住院的病例与非最近的病例相比,与加速认知衰退的相关性更强.
结论:
- 证实并完善了国际上关于住院治疗对认知衰退的影响的研究结果.
- 这种关联依赖于剂量,表现出近期效应,并且独立于cLOS的疾病严重程度.
- 急性住院可能是认知能力下降的可逆风险因素,需要对家庭护理和神经炎症进行干预和进一步研究.
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