N-到C-合成,可以说是可持续生产的未来
Kinshuk Ghosh1, William D Lubell1
1Département de Chimie, Université de Montréal, Québec, Canada.
概括
固相合成 (SPPS) 已经彻底改变了生产,但在效率方面面临挑战. 另一个N向C方向的SPPS提供了更可持续的方法,减少了浪费和保护需求.
科学领域:
- 化学合成 化学合成
- 有机化学 有机化学
- 生物技术是生物技术.
背景情况:
- 碳氧酸到氨基 (C-到N-) 固相合成 (SPPS) 是现代科学的一个基石.
- 由于保护组和过剩的试剂,C-到N-SPPS的过程质量强度高,原子经济性差.
- 这就需要探索替代的,更可持续的制造方法.
研究的目的:
- 审查新兴的氨基到碳酸盐 (N-到C-) 合成领域.
- 突出N-到C-SPPS在可持续酸生产中的优势.
- 为了比较C-到N-SPPS和N-到C-SPPS的效率和废物概况.
主要方法:
- 关于N-到C-合成方法的现有文献的审查.
- 对N至C方向的胺键形成策略的分析,包括铁,乙烯基和转化.
- 对C-到N-SPPS和N-到C-SPPS的保护组策略和试剂使用的评估.
主要成果:
- N-到C-合成为最小化保护策略提供了潜力.
- 类似于铁,乙烯基和转amidation 的方法使得高效的氨基酸结合形成具有低的epimerization.
- 与传统的C-到N-SPPS相比,N-到C-SPPS可以减少浪费和改善原子经济.
结论:
- N-到C-合成为更绿色和更高效的制造提供了一个有前途的途径.
- 采用N-到C-SPPS可以显著提高类产业的可持续性.
- 对N-到C-SPPS方法的进一步研究可以推动酸生产的创新.
更多相关视频
13:34Production, Crystallization and Structure Determination of C. difficile PPEP-1 via Microseeding and Zinc-SAD
Published on: December 30, 2016
11.5K
08:48Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Published on: January 26, 2016
11.7K
相关概念视频
01:58Cell Specific Gene Expression
13.3K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.3K
01:25Insulin: Biosynthesis, Chemistry, and Preparation
303
The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
303
01:20The Central Dogma
19.3K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
19.3K