大脑小血管疾病和认知功能障碍与中央缩血压相关
Zhongping Yu1, Zihao Chen1, Chang Chen1
1Department of Cardiology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China; NHC Key Laboratory of Assisted Circulation and Vascular Diseases, Sun Yat-Sen University, Guangzhou, Guangdong, China.
European journal of internal medicine
|May 1, 2025
概括
中枢收缩血压 (cSBP) 与大脑小血管疾病 (CSVD) 和认知能力下降有关. 这些关联在黑人中更强,表明cSBP可能有助于CSVD预防策略.
科学领域:
- 神经学 神经学
- 心血管健康 心血管健康
- 老年学是一门学科.
背景情况:
- 高血压 (BP) 是脑小血管疾病 (CSVD) 和认知障碍的已知危险因素.
- 脑神经系统疾病,认知功能障碍和中心血压 (cSBP) 之间的关系仍未得到充分研究.
研究的目的:
- 为了研究中央缩血压 (cSBP) 与大脑小血管疾病 (CSVD) 和认知功能标志物之间的关联.
- 评估cSBP对CSVD在多样化的老龄化人口中的预测价值.
主要方法:
- 利用了1447名社区动脉样硬化风险 (ARIC) 研究参与者的数据 (平均年龄为76.0岁).
- 通过使用MRI定义的白质超强度体积 (log-WMHv),内心梗塞和微出血来评估CSVD.
- 通过迷你精神状态检查测量认知功能,通过应用度测量测量中心缩血压 (cSBP).
主要成果:
- cSBP与白质高强度体积和叶膜/皮下皮层微出血有显著联系.
- cSBP改善了预测叶膜微出血的模型性能,超过了外围SBP.
- 在黑人参与者中,cSBP,CSVD标志物和认知功能障碍之间的关联明显更强.
结论:
- 中心缩血压独立地与大脑小血管疾病和认知障碍有关.
- cSBP可以作为一种有价值的生物标志物,用于识别患有CSVD风险的个人.
- 为了制定有效的CSVD预防策略,需要对cSBP进行进一步的研究.
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