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视觉脂肪指数作为代谢功能障碍相关的脂肪性肝病的预测指标:一个横截面研究

Tuo Zhou¹, Xiang Ding¹, Linjie Chen¹

¹Department of Gastroenterology, Yueyang Central Hospital, Yueyang, 414000, China.

BMC gastroenterology

|May 1, 2025

概括

较高的内脏脂肪指数 (VAI) 与代谢功能障碍相关的脂肪性肝病 (MASLD) 风险增加有关. 然而,像LAP和FLI这样的简单得分是MASLD的更好的诊断工具.

科学领域:

代谢健康代谢健康
肝病学肝病学是一种肝病学.
肥胖研究的研究.

背景情况:

内脏脂肪指数 (VAI) 与代谢功能障碍相关的脂肪性肝病 (MASLD) 之间的联系需要澄清.
内脏脂肪是代谢障碍的一个已知的危险因素.

研究的目的:

调查VAI和MASLD风险之间的关联.
将VAI的诊断性能与MASLD的既定非侵入性得分进行比较.

主要方法:

利用了2017-2018年国家健康和营养检查调查 (NHANES) 的数据.
采用加权多变量回归,子组分析和机器学习算法.
评估了MASLD的VAI,LAP和FLI的关联和预测准确性.

主要成果:

较高的VAI三角动物与增加的MASLD风险 (OR=7.08) 有显著的相关性.
机器学习模型 (随机森林,GBM) 显示出高的预测准确性 (AUC ≈ 0.869).
与VAI (AUC=0.736) 相比,脂质积累产物 (LAP) 和脂肪肝指数 (FLI) 显示出更高的诊断性能 (AUC ≈0.834).

结论:

VAI与较高的MASLD风险有显著的关联.
LAP和FLI是MASLD比VAI更有效和临床实用的非侵入性诊断工具.
这些发现强调了选择适合MASLD评估的生物标志物的重要性.

关键词:

机器学习机器学习与代谢功能障碍相关的脂肪性肝病.国家健康和营养检查调查调查非侵入性得分的得分.内脏脂肪度指数是什么意思

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