肠道微生物群及其对脑癌环境的影响
Bandari BharathwajChetty1, Aviral Kumar1, Pranav Deevi1,2
1Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, 781039, Assam, India.
Journal of neuroinflammation
|May 1, 2025
概括
肠道微生物失衡 (失生症) 影响大脑功能,并与质瘤等脑癌有关. 本综述探讨了肠道微生物及其代谢物如何影响脑瘤的进展和治疗.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 在瘤学瘤学.
背景情况:
- 人的肠道微生物群在生理过程中起着至关重要的作用,包括新陈代谢和免疫调节.
- 在肠道微生物组和认知功能之间存在复杂的相互作用.
- 肠道微生物失调症越来越多地与神经系统疾病和癌症有关.
研究的目的:
- 审查肠道失生症在脑癌,包括质瘤和质母细胞瘤的进展中的机制性作用.
- 阐明微生物代谢物对瘤发育的影响.
- 探索肠道微生物群作为治疗点和生物标志物的潜力.
主要方法:
- 文献综述侧重于研究肠-大脑轴和脑癌的研究.
- 对微生物代谢物 (例如短链脂肪酸,氨基酸,脂质) 和它们对瘤发生的影响的研究分析.
- 对微生物群介导的治疗反应研究的审查.
主要成果:
- 肠道功能失调会破坏认知平衡,并与大脑癌症的发展有关.
- 微生物代谢物显著调节大脑中的瘤进展.
- 肠道微生物群影响癌症治疗方案的有效性.
结论:
- 失生症介导的机制对于脑癌的进展至关重要.
- 准肠道微生物群及其代谢物为新的治疗策略提供了潜力.
- 肠道微生物群作为大脑癌症早期检测和治疗监测的生物标志物具有前途.
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