每日24小时活动周期与事件痴呆症之间的关联
David A Raichlen, Daniel H Aslan1, M Katherine Sayre2
1Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA.
Medicine and science in sports and exercise
|May 2, 2025
概括
减少久坐时间和增加中度至强度的体力活动 (MVPA) 是预防痴呆症的关键. 将时间重新分配给久坐行为 (SB) 会增加痴呆症的风险,而转向MVPA会减少它.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 身体活动,久坐不动的行为和睡眠影响痴呆风险.
- 24小时的时间限制使理解对痴呆症的行为影响变得复杂.
- 这项研究调查了睡眠,久坐行为 (SB),轻度体力活动 (LPA) 和中度至强度体力活动 (MVPA) 和痴呆风险之间的时间重新分配.
研究的目的:
- 检查睡眠,SB,LPA和MVPA之间重新分配时间对老年人痴呆风险的影响.
- 量化与24小时内不同日常活动之间转移时间相关的痴呆风险.
主要方法:
- 使用了英国生物银行数据集 (n=51,314) 的组成数据分析.
- 使用手腕加速度计和机器学习测量睡眠,SB,LPA和MVPA.
- 在平均6.61年的随访期间使用了考克斯的比例危险模型.
主要成果:
- 从其他行为重新分配1小时/天到SB增加了114%的痴呆风险 (HR=2.14).
- 从其他行为转移1小时/天到MVPA,痴呆风险降低了17% (HR=0.83).
- 转换到睡眠或LPA没有显著的影响,除非它们改变了SB或MVPA时间.
结论:
- 减少久坐时间和增加MVPA对于降低痴呆风险至关重要.
- 针对久坐行为和MVPA的干预措施对于预防痴呆和大脑健康至关重要.
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