血清25-基维生素D与肉类肥胖风险的关联:英国生物银行的一项纵向观察研究
Qian Xu1,2, Fan Bu2, Zi-Tong Song2
1Department of Orthopedics, Taicang Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.
Obesity (Silver Spring, Md.)
|May 2, 2025
概括
较高的血清25-氧维生素D (25[OH]D) 水平与男性和女性患上形肥胖 (SO) 的风险降低有关. 这种反向关系表明,维生素D可能对SO发生率起着保护作用.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 肥胖症 (SO) 是一个越来越严重的健康问题,其特点是肌肉质量的减少和脂肪质量的增加.
- 血清25-氧维生素D (25[OH]D) 是维生素D状态的关键指标,在肌肉和脂肪代谢中具有潜在的作用.
- 了解与SO发生率相关的因素对于制定有效的预防策略至关重要.
研究的目的:
- 调查血清25-氧维生素D (25[OH]D) 度与肉骨肥胖 (SO) 的发生率之间的关联.
- 探索这种关联中的潜在剂量反应关系和性别特异性差异.
主要方法:
- 利用来自英国生物库队列 (N=46,535) 的纵向观测数据.
- 采用Cox的比例危险模型来评估基于血清25[OH]D度的四分位数的SO发病率风险.
- 进行多变量调整和受限立方线分析以评估线性和非线性关联.
主要成果:
- 在较高的血清25[OH]D水平和SO发病率的风险之间观察到显著的反向关联.
- 25[OH]D较高四分位数的个体与最低四分位数相比,对SO发展的危险比率明显较低.
- 在女性 (p=0.043) 和男性 (p=0.008) 参与者中证实了非线性关联,表明了剂量-反应关系.
结论:
- 血清25[OH]D度升高显著与低于型肥胖发病率的风险有关.
- 这些发现表明,维生素D对SO具有保护作用,具有明确的剂量反应关系.
- 对预防SO的维生素D补充剂的进一步研究是有必要的.
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