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相关概念视频

Phosphorylation01:02

Phosphorylation

49.6K
The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
49.6K
Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives01:35

Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives

1.9K
Just like β-keto acids—which upon thermal decarboxylation form ketones—β-dicarboxylic acids undergo decarboxylation to generate monocarboxylic acids with the liberation of carbon dioxide.
1.9K
Aldehydes and Ketones to Alkenes: Wittig Reaction Mechanism01:14

Aldehydes and Ketones to Alkenes: Wittig Reaction Mechanism

3.2K
The Wittig reaction, which converts aldehydes or ketones to alkenes using phosphorus ylides, proceeds through a nucleophilic addition‒elimination process.
The reaction begins with the nucleophilic addition between a phosphorus ylide and the carbonyl compound. Due to its carbanionic character,  phosphorus ylide acts as a strong nucleophile and attacks the electrophilic carbonyl group. This generates a charge-separated dipolar intermediate called betaine. The negatively charged oxygen...
3.2K
Loss of Carboxy Group as CO2: Decarboxylation of β-Ketoacids01:02

Loss of Carboxy Group as CO2: Decarboxylation of β-Ketoacids

3.1K
Carboxylic acids, upon heating, undergo a decarboxylation reaction by releasing carbon dioxide gas. Monocarboxylic acids do not undergo decarboxylation easily. However, a silver salt of carboxylic acid reacts with bromine or iodine under high temperature to release carbon dioxide gas and forms halide with one less carbon. This reaction is called the Hunsdiecker reaction.
3.1K
Aldehydes and Ketones to Alkenes: Wittig Reaction Overview01:19

Aldehydes and Ketones to Alkenes: Wittig Reaction Overview

7.5K
The Wittig reaction is the conversion of carbonyl compounds—aldehydes and ketones—to alkenes using phosphorus ylides, or the Wittig reagent. The reaction was pioneered by Prof. Georg Wittig, for which he was awarded the Nobel Prize in Chemistry.
7.5K
Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

13.0K
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
13.0K

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相关实验视频

Updated: May 17, 2025

Light-driven Enzymatic Decarboxylation
09:58

Light-driven Enzymatic Decarboxylation

Published on: May 22, 2016

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光诱导的脱碳氧化化化.

Zhen-Zhen Liu1, Chong-Jin Zhang1, Jian-Ping Qu1

  • 1School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

The Journal of organic chemistry
|May 2, 2025
PubMed
概括
此摘要是机器生成的。

一种新的可见光方法可以使N-基胺基与酸盐或酸盐的脱基合. 这种方法为功能化酸盐和氧化物提供了成本高效和无金属的途径.

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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

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Preparation and Use of Carbonyl-decorated Carbenes in the Activation of White Phosphorus
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Preparation and Use of Carbonyl-decorated Carbenes in the Activation of White Phosphorus

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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
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Preparation and Use of Carbonyl-decorated Carbenes in the Activation of White Phosphorus
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科学领域:

  • 有机化学 有机化学
  • 摄影化学的使用.
  • 激进的反应 激进的反应

背景情况:

  • N-甲胺 (N-hydroxyphthalimide,NHPI) 是激素生成的多功能前体.
  • 含的化合物在各种化学和生物应用中至关重要.
  • 现有的合成酸盐和氧化物的方法通常涉及恶劣的条件或有毒试剂.

研究的目的:

  • 开发一种新的可见光诱导方法,用于脱碳化基结合.
  • 为了高效地合成功能化酸盐和氧化物.
  • 为化合物合成提供可持续且无金属的替代品.

主要方法:

  • 可见光光电还原催化.
  • 脱碳氧化基结合反应.脱碳氧化基结合反应.
  • 使用N-hydroxyphthalimide Ester作为激素前体.
  • 使用石或石作为合伙伴.

主要成果:

  • 取得了成功的可见光诱导的脱碳氧化基结合.
  • 合成了一系列功能化酸盐和氧化.
  • 反应在温和条件下进行.
  • 不需要过渡金属或有毒试剂.

结论:

  • 已经建立了一种实用且低成本的方法来合成酸盐和氧化物.
  • 这种可见光介导的方法为传统合成路线提供了更绿色的替代方案.
  • 该方法适用于生产各种功能化化合物.