生命线队列中的功能和内化障碍的家族聚合和共享家族关系
Martje Bos1, Rei Monden1,2, Naomi R Wray3,4
1Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Psychological medicine
|May 2, 2025
概括
功能障碍 (FD) 和内化障碍 (ID) 具有共同的家族风险因素,表明共同的遗传和环境影响. 肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 显示出与内化疾病最强的家族联系.
科学领域:
- 遗传学和流行病学
- 精神病学和行为医学
- 公共卫生 公共卫生
背景情况:
- 功能障碍 (FDs) 经常与内化障碍 (IDs) 相伴,这表明它们有共同的潜在病因.
- 了解FD和ID的家族聚合对于阐明它们的起源至关重要.
研究的目的:
- 调查特定的FD和ID之间的家族聚合和共享的亲属关系.
- 量化FDs的家族组成部分及其与IDs的重叠.
主要方法:
- 利用了来自153,803个人的三代生命线队列研究数据.
- 使用诊断标准评估了三种FD (ME/CFS,IBS,FM) 和六种ID (MDD,DYS,GAD,AGPH,SPH,PD).
- 计算的复发风险比率 (λRs) 和四重相关性,以评估家族聚合和相关性.
主要成果:
- 对于单个疾病和不同类型的疾病都发现了显著的家族聚合.
- 据估计,FD家族性范围从IBS的22%到ME/CFS的42%不等.
- 在某些FD和ID之间观察到很高的家族相关性,特别是MDD和ME/CFS (+0.83).
结论:
- 对于FDs,有一个独特的家族组成部分,它与IDs部分共享.
- 共同的遗传和家庭环境风险因素可能会导致FD和ID的共患.
- ME/CFS在被研究的患有内化障碍的FD中显示出最密切的家族关系.
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